Novel Copper Coordination Polymers Incorporating Dual Auxiliary Ligand Systems: Enhanced Urease Inhibition Mechanisms

The development of efficient urease inhibitors has become increasingly important due to their potential applications in agricultural and biomedical fields. This comprehensive study investigates novel copper coordination polymers incorporating dual auxiliary ligand systems and their enhanced urease inhibition mechanisms. The research explores the synthesis, structural characterization, and biological evaluation of copper-based coordination polymers with specific focus on their urease inhibitory activities. Recent advances in coordination polymer chemistry have demonstrated that copper complexes with carefully designed auxiliary ligand systems exhibit superior urease inhibition compared to conventional inhibitors. The dual auxiliary ligand approach allows for fine-tuning of the coordination environment around copper centers, leading to optimized binding interactions with the urease enzyme. Through systematic investigation of structure-activity relationships, this work elucidates the fundamental mechanisms underlying enhanced urease inhibition in these novel copper coordination polymers. The findings reveal that the incorporation of dual auxiliary ligands not only improves the stability of the coordination frameworks but also enhances their biological activity through multiple binding modes. These results provide valuable insights for the rational design of next-generation urease inhibitors with potential applications in treating urease-related diseases and agricultural nitrogen management.