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Comparative Efficacy of Tranexamic Acid Versus Vitamin C in the Treatment of Melasma with Microneedling

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  • Aguilera, Denisse Díaz
  • Pérez, Kendry Morales
  • Aguilera, Linet Laura Díaz
  • Ferras, Sara Mosquera

Abstract

Melasma is a common pigmentary dermatosis in women that affects quality of life and is resistant to conventional treatments. This study analyzed the efficacy of tranexamic acid and vitamin C (ascorbic acid), associated with microneedling, in a sample of six women drawn from a population of 10 candidates. Variables such as age, lesion evolution time, number of sessions, and clinical differences between both treatments were evaluated. The results indicated a significant reduction in the melanin index in both groups, with moderate statistical superiority in the tranexamic acid group. Mechanisms of action, limitations, and clinical recommendations are discussed.

Suggested Citation

  • Aguilera, Denisse Díaz & Pérez, Kendry Morales & Aguilera, Linet Laura Díaz & Ferras, Sara Mosquera, 2026. "Comparative Efficacy of Tranexamic Acid Versus Vitamin C in the Treatment of Melasma with Microneedling," SAP Primary Care, South American Publishing.
    • Handle: RePEc:cwf:pcarti:pc2026123
    DOI: 10.62486/pc2026123
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