IDEAS home Printed from https://ideas.repec.org/a/cwf/pcarti/pc202518.html

Comparison of clinical efficacy and dosing regimens between Nirsevimab and Palivizumab for prophylaxis against RSV in the pediatric population

Author

Listed:
  • María Pellecchia, Lucila
  • Manuel Correa, Facundo Juan

Abstract

Background: Respiratory syncytial virus is a major cause of lower respiratory tract infections in infants, leading to significant hospitalization rates in Argentina. For decades, Palivizumab was the only effective prophylactic option, but its multiple-dose regimen and limited accessibility reduced its impact. Nirsevimab, a long-acting monoclonal antibody, emerges as an innovative alternative, providing sustained protection with a single seasonal dose. Methods: A systematic literature review was conducted using PubMed, MEDLINE, Embase, and SciELO, including systematic reviews, meta-analyses, observational studies, and pediatric society guidelines published up to April 2024. Results: Nirsevimab demonstrated a significant reduction in hospitalizations related to RSV, surpassing Palivizumab and improving adherence. When combined with maternal vaccination, its effectiveness and cost-efficiency were further enhanced across multiple clinical settings. Conclusion: Nirsevimab represents a highly effective, safe, and easy-to-implement strategy with the potential to transform infant RSV prevention policies. However, additional studies in local populations are essential to evaluate long-term effectiveness, feasibility, and sustainability.

Suggested Citation

  • María Pellecchia, Lucila & Manuel Correa, Facundo Juan, 2025. "Comparison of clinical efficacy and dosing regimens between Nirsevimab and Palivizumab for prophylaxis against RSV in the pediatric population," SAP Primary Care, South American Publishing.
    • Handle: RePEc:cwf:pcarti:pc202518
    DOI: 10.62486/pc202518
    as

    Download full text from publisher

    File URL: https://southam.pub/journals/files/pc/pc202518en.pdf
    Download Restriction: no
    File URL: https://southam.pub/journals/files/pc/pc202518es.pdf
    Download Restriction: no
    File URL: https://libkey.io/10.62486/pc202518?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:cwf:pcarti:pc202518. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: South American Publishing Journals Manager (email available below). General contact details of provider: https://southam.pub/journals/pc.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.