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Analysis of antibody titers according to anti-SARS-CoV-2 vaccination schedules, assessed through protein S, discriminated according to history of Covid-19 disease, comorbidities, age and sex in San Lorenzo city

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  • González, Yasmin

Abstract

The present study analyzes the humoral immune response in 319 inhabitants of San Lorenzo, Argentina, vaccinated with two doses of different anti-SARS-CoV-2 vaccines. The results show that almost all participants developed Anti-S antibodies, with the Sinopharm vaccine being less effective compared to AstraZeneca, Sputnik V and Moderna. The population was divided according to variables such as sex, age, history of Covid-19 and comorbidities, and it was evident that both people with a history of the disease and those with comorbidities had elevated antibody levels. No significant differences in immunogenicity were found with respect to sex or age, confirming a high response in older adults. The main limitation was a fixed cut-off point of 250 U/ml, which prevented detailed comparisons between schemes. This study suggests the effectiveness of all vaccination schedules studied and underlines the need for future research on the durability of the immune response.

Suggested Citation

  • González, Yasmin, 2023. "Analysis of antibody titers according to anti-SARS-CoV-2 vaccination schedules, assessed through protein S, discriminated according to history of Covid-19 disease, comorbidities, age and sex in San Lorenzo city," SAP Multidisciplinary Open, South American Publishing.
    • Handle: RePEc:cwf:moarti:mo202321
    DOI: 10.62486/mo202321
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