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Transcriptomic features add little to staging for oral cavity squamous cell carcinoma prognosis

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  • Diaz, Arlin Castro
  • arlincastrodiaz02@gmail.com
  • Fritze, Rigel Ramirez
  • rigelramirezf1021@gmail.com

Abstract

Introduction: Gene expression signatures are widely proposed to improve the prognosis of oral cavity squamous cell carcinoma, but whether they add value over clinical staging remains contested. Methods: A total of 101 oral cavity squamous cell carcinoma cases with transcriptomic and survival data from TCGA-HNSC were analyzed. Cox models using stage alone, stage and age, and a combined model adding 30 univariate-selected genes were compared by five-fold cross-validated concordance index. Results: The concordance index was 0.645 for stage alone, 0.670 for stage and age, and 0.640 for the combined model. The combined model did not exceed stage alone (difference -0.004), and age added the only meaningful gain. Conclusions: Transcriptomic features selected by univariate association did not improve survival discrimination over clinical staging in this oral cavity cohort.

Suggested Citation

  • Diaz, Arlin Castro & arlincastrodiaz02@gmail.com & Fritze, Rigel Ramirez & rigelramirezf1021@gmail.com, 2026. "Transcriptomic features add little to staging for oral cavity squamous cell carcinoma prognosis," SAP Artificial Intelligence in Dentistry, South American Publishing.
    • Handle: RePEc:cwf:aidart:aid2026150
    DOI: 10.62486/aid2026150
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