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Spectrophotometric Determination of L-Ascorbic Acid in Pharmaceuticals based on Its Oxidation by Potassium Peroxydisulfate in the Presence of Ag(I) as a Catalyst

Author

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  • Amra Selimović
  • Mirsad Salkić
  • Halid Junuzović

Abstract

New accurate, precise, and sensitive spectrophotometric method were developed for the assay of L-ascorbic acid in pharmaceutical preparations. The determination of L-ascorbic acid was based on its oxidation by potassium peroxydisulfate in the presence of Ag(I) as a catalyst. The molar absorptivity of the proposed method was found to be 8.61 · 103 L mol-1 cm-1 at 248 nm. Beer's law was obeyed in the concentration range of 0.46–20.0 μg mL–1. Other compounds commonly found in vitamin C and multivitamin products did not interfere with the determination of L-ascorbic acid. The proposed method was successfully applied for the determination of L-ascorbic acid in pharmaceutical formulations. The results obtained with the proposed method showed good agreement with those given by the titrimetric method using iodine.

Suggested Citation

  • Amra Selimović & Mirsad Salkić & Halid Junuzović, 2024. "Spectrophotometric Determination of L-Ascorbic Acid in Pharmaceuticals based on Its Oxidation by Potassium Peroxydisulfate in the Presence of Ag(I) as a Catalyst," International Journal of Scientific Research in Chemistry, International Journal of Scientific Research in Chemistry, vol. 9(3), pages 09-16, May.
    • Handle: RePEc:cuo:ijsrch:v9:y2024:i3:id:6
    DOI: 10.32628/IJSRCH24932
    Note: Article URL: https://ijsrch.com/home/article/view/IJSRCH24932
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