Green Synthetic Strategy for the Development of Novel Thiazolidinone-Functionalized Benzothiazole–Triazole Hybrids

The worldwide emergence of bacterial resistance has become a major public health concern, threatening the therapeutic efficacy of existing antibiotics. Consequently, there is an urgent need to discover and develop novel, effective antimicrobial agents. In view of this challenge, the present study describes the convenient one-pot synthesis of two new classes of benzothiazole–triazole hybrids and thiazolidinone-linked benzothiazole–triazole hybrids through a molecular hybridization strategy. The newly synthesized compounds were evaluated for their antimicrobial potential against selected bacterial and fungal strains. Among the synthesized derivatives, compounds containing methoxyphenyl substituents and heteroaromatic rings demonstrated notable microbial growth-inhibitory activity. The findings of this study indicate that the incorporation of a thiazolidinone moiety into benzothiazole–triazole hybrids may provide a promising structural framework for the development of biologically active antimicrobial molecules. Furthermore, the proposed synthetic methodology offers a sustainable and environmentally benign approach, as it proceeds without the use of metals or catalysts. The protocol also accommodates a wide range of functional groups and requires relatively short reaction times, affording the desired bioactive scaffolds in moderate to excellent yields.