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Triazole as a Privileged Scaffold: Recent Progress in Antibacterial and Antifungal Drug Development

Author

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  • Nivrutti Ambadkar
  • Kishore Puri
  • Santosh B. Gaikwad

Abstract

The triazole scaffold is a crucial component of heterocyclic chemistry, serving as a basic building block in organic synthesis, materials science, and medicinal chemistry. Triazole is a five membered ring composed of three nitrogen atoms and two carbon atoms, and it exists in two isomeric forms: 1,2,3-triazole and 1,2,4-triazole. Compounds featuring the triazole ring are important heterocycles known for their diverse biological activities, including antimicrobial, antiproliferative, antimalarial, anticonvulsant, anti-inflammatory, antineoplastic, antiviral, analgesic, and anticancer properties. As a result, triazole derivatives have attracted significant attention from researchers. This review aims to provide a thorough overview of the published studies on the synthesis of triazole derivatives, highlighting various methods for obtaining the triazole moiety. These methods include classical approaches as well as microwave and ultrasound-assisted techniques.

Suggested Citation

  • Nivrutti Ambadkar & Kishore Puri & Santosh B. Gaikwad, 2026. "Triazole as a Privileged Scaffold: Recent Progress in Antibacterial and Antifungal Drug Development," International Journal of Scientific Research in Chemistry, International Journal of Scientific Research in Chemistry, vol. 11(4), pages 37-46, July.
  • Handle: RePEc:cuo:ijsrch:v11:y2026:i4:id:101
    DOI: 10.32628/IJSRCH241145
    Note: Article URL: https://ijsrch.com/home/article/view/IJSRCH241145
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