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Eco-friendly Synthesis, Characterization and Antimicrobial Activity of Transition Metal Complexes of Schiff Base Ligand Derived from 1H-indole-3-carbaldehyde with 3-methylpyridine-4-carbohydrazide

Author

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  • Sadashiv N. Sinkar

Abstract

A Novel Schiff base ligand derived from (E)-N'-((1H-indol-3-yl) methylene)-3-methylpyridine-4-carbohydrazide was synthesized, along with its transition metal complexes of Mn (II), Co (II), Ni (II), Cu (II), and Zn (II), using microwave irradiation as a green approach, contrasting with conventional methods. The structure of these compounds was thoroughly characterized through elemental and spectroscopic analyses, including IR, 1H-NMR, and electronic spectra, elucidating their geometrical arrangements. Furthermore, the thermal stability of the Mn (II) and Co (II) complexes was investigated via thermo-gravimetric analyses (TGA). Elemental analysis confirmed a metal-to-ligand stoichiometry of 1:2 molar ratio. Additionally, the complexes were screened for their potential biological activities, particularly antimicrobial properties.

Suggested Citation

  • Sadashiv N. Sinkar, 2026. "Eco-friendly Synthesis, Characterization and Antimicrobial Activity of Transition Metal Complexes of Schiff Base Ligand Derived from 1H-indole-3-carbaldehyde with 3-methylpyridine-4-carbohydrazide," International Journal of Scientific Research in Chemistry, International Journal of Scientific Research in Chemistry, vol. 11(3), pages 15-23, May.
    • Handle: RePEc:cuo:ijsrch:v11:y2026:i3:id:92
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