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Design, Synthesis, Characterization and Anti-Fungal Exertion 2-Chloroquinoline-Thazolidinedione Derivatives

Author

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  • Krunal V. Juddhawala
  • Nikhil M. Parekh

Abstract

A variety of new compounds have been integrated into the structural framework of (5Z)-5-[(2-(4-phenylpiperazin-1yl)quinoline-3-yl)methyl]-1,3-thiazolidine-2,4-dione. The synthesis of 1,3-thiazolidine-2,4-dione was accomplished by means of the condensation of 2-chloroquinoline, which later functioned as a pivotal reagent in the reaction with 3-carbaldehydes, resulting in the production of 2,4-thiazolidinedione. Chemical identification was achieved by using elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), and proton nuclear magnetic resonance spectroscopy (1H-NMR). Additionally, the synthesized compounds were subjected to in vitro testing to assess their antifungal activity against a range of pathogens, such as A. niger, C. albicans.

Suggested Citation

  • Krunal V. Juddhawala & Nikhil M. Parekh, 2025. "Design, Synthesis, Characterization and Anti-Fungal Exertion 2-Chloroquinoline-Thazolidinedione Derivatives," International Journal of Scientific Research in Chemistry, International Journal of Scientific Research in Chemistry, vol. 10(6), pages 08-22, November.
    • Handle: RePEc:cuo:ijsrch:v10:y2025:i6:id:65
    DOI: 10.32628/IJSRCH251062
    Note: Article URL: https://ijsrch.com/home/article/view/IJSRCH251062
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