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Biotechnologies et industrie pharmaceutique. Un modèle évolutionnaire conforme à l'histoire


  • Franco Malerba
  • Luigi Orsenigo
  • Sandrine Selosse


This paper is a first attempt at modelling the long term dynamics of market structure and innovation in the pharmaceutical industry in a history-friendly way. The model examines the relationships between the nature of the search space, demand, the patterns of competition and industry evolution in the age of random screening and in the age of molecular biology, and shows that concentration in the pharmaceutical industry is shaped by lack of cumulativeness in innovative activities and market fragmentation. The model conforms to our appreciative understanding and responds to changes in parameters concerning demand, costs, economies of scale, opportunity conditions and the relative advantages of New Biotechnology Firms (NBFs) vis-à-vis incumbents. With the exception of costs increases, the model is quite robust to these changes in its essential features: it is quite difficult to raise substantially concentration and to have NBFs displacing incumbents. JEL codes: L1, L65.

Suggested Citation

  • Franco Malerba & Luigi Orsenigo & Sandrine Selosse, 2006. "Biotechnologies et industrie pharmaceutique. Un modèle évolutionnaire conforme à l'histoire," Revue de l'OFCE, Presses de Sciences-Po, vol. 96(1), pages 157-209.
  • Handle: RePEc:cai:reofsp:reof_096_0157

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    References listed on IDEAS

    1. repec:dau:papers:123456789/4189 is not listed on IDEAS
    2. Valérie Chauvin & Gaël Dupont & Éric Heyer & Mathieu Plane & Xavier Timbeau, 2002. "Le modèle France de l'OFCE. La nouvelle version :," Revue de l'OFCE, Presses de Sciences-Po, vol. 81(2), pages 245-300.
    3. Barro, Robert J, 1979. "On the Determination of the Public Debt," Journal of Political Economy, University of Chicago Press, vol. 87(5), pages 940-971, October.
    4. repec:spo:wpecon:info:hdl:2441/1631 is not listed on IDEAS
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    More about this item

    JEL classification:

    • L1 - Industrial Organization - - Market Structure, Firm Strategy, and Market Performance
    • L65 - Industrial Organization - - Industry Studies: Manufacturing - - - Chemicals; Rubber; Drugs; Biotechnology; Plastics


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