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Efficacy of a new ready-to-use vaccine against PCV-2d and Mycoplasma hyopneumoniae under experimental conditions

Author

Listed:
  • R Krejci

    (Ceva Sante Animale, Libourne Cedex, France)

  • P Trampus

    (Ceva-Phylaxia Zrt., Budapest, Hungary)

  • A Csagola

    (Ceva-Phylaxia Zrt., Budapest, Hungary)

  • T Szalai

    (Ceva-Phylaxia Zrt., Budapest, Hungary)

  • N Palmai

    (Ceva-Phylaxia Zrt., Budapest, Hungary)

  • A Toth

    (Ceva-Phylaxia Zrt., Budapest, Hungary)

  • N Terenyi

    (Ceva-Phylaxia Zrt., Budapest, Hungary)

  • Z Nagy

    (Ceva-Phylaxia Zrt., Budapest, Hungary)

  • NA Szeplaki

    (Ceva-Phylaxia Zrt., Budapest, Hungary)

  • G Somogyi

    (Ceva-Phylaxia Zrt., Budapest, Hungary)

  • T Barna

    (Ceva-Phylaxia Zrt., Budapest, Hungary)

  • E Rausch

    (Ceva-Phylaxia Zrt., Budapest, Hungary)

  • Z Penzes

    (Ceva-Phylaxia Zrt., Budapest, Hungary)

  • M Szaszko

    (TargetEx Biosciences Ltd., Dunakeszi, Hungary)

  • Z Lorincz

    (TargetEx Biosciences Ltd., Dunakeszi, Hungary)

Abstract

Mycoplasma hyopneumoniae (M. hyo) and porcine circovirus type 2 (PCV-2) are major and widespread swine pathogens, both implicated in the porcine respiratory disease complex, which can lead to significant economic losses for pig producers. PCV-2d is currently the most prevalent genotype. Vaccination against these two pathogens helps mitigate their impact on pig health and performance. The use of ready-to-mix or ready-to-use (RTU) vaccines targeting PCV-2a or PCV-2a/b and M. hyo is a common practice. This study aimed to evaluate the efficacy of a novel RTU vaccine containing PCV-2d and M. hyo antigens under experimental conditions. Several challenge trials were conducted using PCV-2a, PCV-2b, PCV-2d, and M. hyo to assess the level of protection conferred against different PCV-2 genotypes and M. hyo, as well as to determine the duration of protection. This study demonstrated that the bivalent PCV-2/M. hyo vaccine induces both early and long-lasting protection against infections caused by M. hyo and PCV-2. In addition, cross-protection against the three major PCV-2 genotypes was confirmed.

Suggested Citation

  • R Krejci & P Trampus & A Csagola & T Szalai & N Palmai & A Toth & N Terenyi & Z Nagy & NA Szeplaki & G Somogyi & T Barna & E Rausch & Z Penzes & M Szaszko & Z Lorincz, 2025. "Efficacy of a new ready-to-use vaccine against PCV-2d and Mycoplasma hyopneumoniae under experimental conditions," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 70(6), pages 196-202.
    • Handle: RePEc:caa:jnlvet:v:70:y:2025:i:6:id:6-2025-vetmed
    DOI: 10.17221/6/2025-VETMED
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