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Allogeneic adipose MSCs and autologous PRP for chronic non-healing wound in a cat

Author

Listed:
  • N Suwan

    (Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand)

  • S Jenjittikul

    (Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand)

  • R Tiratrakoonseree

    (Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand)

  • C Jiradanaipat

    (Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand)

  • S Teerawongsuwan

    (Department of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand)

  • Wi Phathomrapeepong

    (Wipawadee animal clinic, Bangkok, Thailand)

  • W Phanwanich

    (Department of Biomedical Engineering, Faculty of Engineer, Mahidol University, Nakhon Pathom, Thailand
    Petaneer Co., Ltd. Salaya, Nakhon Pathom, Thailand)

  • R Rungsiwiwut

    (Department of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand)

Abstract

Management of chronic non-healing wounds in cats requires a comprehensive approach. This report describes the treatment of a severe open skin wound on the skull using a combined approach involving allogeneic adipose-derived mesenchymal stem cells (MSCs) and autologous platelet-rich plasma (PRP). A 12-year-old neutered male mixed-breed domestic cat presented with a non-healing chronic wound on the skull. The wound extended from the orbital to the occipital area and from the left to the right temporal region. Laboratory test results were positive for feline immunodeficiency virus and impaired kidney function. Sensitivity tests revealed resistance to several antibiotics. Due to limited skin reconstruction options, MSCs were administered subcutaneously at the wound edge once a month for three months. PRP was collected one month after the initial MSC administration and injected at the wound edge monthly between MSC treatments. The wound diameter was measured daily during saline cleaning. The cat received protein-supplemented food daily. Wound healing was observed two weeks after the MSC administration, gradually decreasing in size and closing completely within 5 months. This case demonstrates the successful application of MSCs and PRP for treating chronic wounds in cats.

Suggested Citation

  • N Suwan & S Jenjittikul & R Tiratrakoonseree & C Jiradanaipat & S Teerawongsuwan & Wi Phathomrapeepong & W Phanwanich & R Rungsiwiwut, 2025. "Allogeneic adipose MSCs and autologous PRP for chronic non-healing wound in a cat," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 70(4), pages 143-149.
    • Handle: RePEc:caa:jnlvet:v:70:y:2025:i:4:id:93-2024-vetmed
    DOI: 10.17221/93/2024-VETMED
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    References listed on IDEAS

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    1. J Kim & D Kim & D Seo & H Hwang & Y Kim & T Chung & S Lim & H Lee & M Kim & S Park & H Youn, 2022. "Clinical application of both amniotic membranes and adipose derived mesenchymal stem cells in a cat with a large skin defect," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 67(2), pages 105-111.
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