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Antiviral agents targeting the influenza virus: a review and publication analysis

Author

Listed:
  • L. Eyer

    (Veterinary Research Institute, Brno, Czech Republic)

  • K. Hruska

    (Veterinary Research Institute, Brno, Czech Republic)

Abstract

Influenza is a serious infectious disease, which is life-threatening especially in children, seniors and immunocompromised patients. In addition to vaccination, the development of new anti-influenza agents represents a crucial defence strategy to combat seasonal and pandemic influenza strains. At present most attention is paid to the development of inhibitors of influenza neuraminidase, which has been established as a key drug target for the prophylaxis and treatment of influenza infections. However, the emergence of drug-resistant influenza variants highlights the need of continuously innovative strategies for the development of new drugs with improved antiviral effects, higher safety and increased tolerability. In this review article, an analysis of publications describing anti-influenza agents indexed in the Web of Science® database has been carried out. The most important publications are presented in tables and are characterised by several key words, abstracts and references. The presented publications have been sorted according to five basic criteria: (i) review articles, (ii) design, synthesis and evaluation of new anti-influenza drugs, (iii) major classes of anti-influenza drugs, (iv) combination therapy of influenza infections and (v) influenza drug resistance. The design of this review article allows us to offer a complex overview of known antiviral agents targeting influenza viruses, facilitates easy and rapid orientation in numerous publications written on this subject, and aids the gathering of required data.

Suggested Citation

  • L. Eyer & K. Hruska, 2013. "Antiviral agents targeting the influenza virus: a review and publication analysis," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 58(3), pages 113-185.
    • Handle: RePEc:caa:jnlvet:v:58:y:2013:i:3:id:6746-vetmed
    DOI: 10.17221/6746-VETMED
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    References listed on IDEAS

    as
    1. K. Hruska & M. Franek, 2012. "Sulfonamides in the environment: a review and a case report," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(1), pages 1-35.
    2. M. Vass & K. Hruska & M. Franek, 2008. "Nitrofuran antibiotics: a review on the application, prohibition and residual analysis," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 53(9), pages 469-500.
    3. Jason R. Schnell & James J. Chou, 2008. "Structure and mechanism of the M2 proton channel of influenza A virus," Nature, Nature, vol. 451(7178), pages 591-595, January.
    4. K. Hruska & M. Kaevska, 2012. "Mycobacteria in water, soil, plants and air: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(12), pages 623-679.
    5. L. Eyer & K. Hruska, 2012. "Single-domain antibody fragments derived from heavy-chain antibodies: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(9), pages 439-513.
    Full references (including those not matched with items on IDEAS)

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