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Total antioxidant capacity in dogs with gastric dilatation and volvulus

Author

Listed:
  • I. Uhrikova

    (Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

  • K. Rehakova

    (Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

  • L. Rauserova-Lexmaulova

    (Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

  • A. Lojek

    (Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

  • J. Doubek

    (Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

Abstract

The aim of this study was to determine total antioxidant capacity in dogs with gastric dilatation-volvulus syndrome (GDV) and its correlations with high mobility group box 1 protein (HMGB1) and lactate concentrations. Correlation analyses between the measured parameters and disease severity were also performed. Fourteen dogs with GDV and six control dogs were used in this study. Blood was collected at the time of admission and again in the early reperfusion period. To assess antioxidant capacity, total radical-trapping antioxidant parameter (TRAP) analysis was performed. No significant difference in TRAP values existed between healthy dogs and dogs with GDV at admission. In the reperfusion period, TRAP values decreased in six dogs and increased in eight dogs. Changes in TRAP values strongly correlated with HMGB1 values (r = -0.83, P < 0.01) in the reperfusion period. Strong correlations between disease severity and TRAP values, HMGB1 and lactate levels were also found.

Suggested Citation

  • I. Uhrikova & K. Rehakova & L. Rauserova-Lexmaulova & A. Lojek & J. Doubek, 2012. "Total antioxidant capacity in dogs with gastric dilatation and volvulus," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(4), pages 207-211.
    • Handle: RePEc:caa:jnlvet:v:57:y:2012:i:4:id:5918-vetmed
    DOI: 10.17221/5918-VETMED
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