IDEAS home Printed from https://ideas.repec.org/a/caa/jnlvet/v57y2012i10id6365-vetmed.html
   My bibliography  Save this article

Three combinations of clonidine in association with tiletamine-zolazepam for anaesthesia induction in rats: evaluation of reflexes and pain sensibility

Author

Listed:
  • G. Spinella

    (University of Catanzaro, Germaneto, Italy)

  • J.M. Vilar

    (Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Gran Canaria, Spain)

  • C. Anastasi

    (Veterinary practitioner, Catanzara, Italy)

  • A. Santana

    (Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Gran Canaria, Spain)

  • U. Prati

    (University of Catanzaro, Germaneto, Italy)

  • L. Roveda

    (University of Catanzaro, Germaneto, Italy)

  • G. Ricciardi

    (Veterinary Practitioner, Vicenza, Italy)

  • D. Britti

    (University of Catanzaro, Germaneto, Italy)

Abstract

The aim of this study was to assess the combination of tiletamine-zolazepam (Zoletil 20®) with three different doses of clonidine for general anaesthesia induction in rats submitted to vascular microsurgery. The evaluation of anaesthetic and analgesic effects was performed in 30 Wistar rats randomly divided into three groups and induced with Zoletil 20 [90 mg/kg Intraperitoneal (IP)] associated with three different doses of clonidine (60-90-120 μg/kg IP). Four clinical parameters were evaluated after induction: loss of righting reflex, voluntary movement, the pedal withdrawal response, and pain sensitivity tested by pinching the tail. The combination of Zoletil with 90 and 120 μg/kg of clonidine provided a surgical anaesthesia; however, 90 μg/kg of clonidine provided the most rapid anaesthesia induction, as confirmed by data obtained by clinical evaluation of the loss of the pedal withdrawal response and the absence of the tail pinch response. The increase in dose of clonidine did not lead to a more rapid action of the α2 agonist, probably due to achievement of a dose-dependent plateau.

Suggested Citation

  • G. Spinella & J.M. Vilar & C. Anastasi & A. Santana & U. Prati & L. Roveda & G. Ricciardi & D. Britti, 2012. "Three combinations of clonidine in association with tiletamine-zolazepam for anaesthesia induction in rats: evaluation of reflexes and pain sensibility," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(10), pages 536-542.
    • Handle: RePEc:caa:jnlvet:v:57:y:2012:i:10:id:6365-vetmed
    DOI: 10.17221/6365-VETMED
    as

    Download full text from publisher

    File URL: http://vetmed.agriculturejournals.cz/doi/10.17221/6365-VETMED.html
    Download Restriction: free of charge
    File URL: http://vetmed.agriculturejournals.cz/doi/10.17221/6365-VETMED.pdf
    Download Restriction: free of charge
    File URL: https://libkey.io/10.17221/6365-VETMED?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to

    for a different version of it.

    More about this item

    Keywords

    ;
    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:caa:jnlvet:v:57:y:2012:i:10:id:6365-vetmed. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Ivo Andrle (email available below). General contact details of provider: https://www.cazv.cz/en/home/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.