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The mechanism of N-carbamylglutamate promoting arginine synthesis and its application in pig production: A review

Author

Listed:
  • Pei Mao

    (College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, P.R. China)

  • MengMeng Gao

    (College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, P.R. China)

  • Naizhi Hu

    (College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, P.R. China)

  • XiaoLi Zhang

    (College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, P.R. China)

  • Yan ChengGang

    (Henan Beimuda Agriculture and Animal Husbandry Co., LTD, Henan, P.R. China)

  • ChengSheng Song

    (Henan Spring Agriculture and Animal Husbandry Technology Co., LTD, Henan, P.R. China)

  • WenFeng Ma

    (College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, P.R. China)

Abstract

Arginine (Arg) is an essential amino acid that can improve the reproductive capacity, intestinal development, and growth performance of pigs. N-carbamylglutamate (NCG) and N-acetylglutamate (NAG) can activate carbamyl phosphate synthetase I and the Δ1 pyrrolin 5 carboxylate synthetase in mitochondria, promoting the synthesis of citrulline from glutamine and proline, citrulline is the main precursors for the synthesis of Arg, and subsequently increasing the endogenous synthesis of Arg to produce nitric oxide (NO) and polyamines. Compared with Arg, NCG has a longer half-life and does not inhibit the absorption of basic amino acids such as histidine or lysine; thus, it has been developed as a feed additive. This paper reviews the application of NCG as a feed additive in pig production and its possible theoretical mechanism.

Suggested Citation

  • Pei Mao & MengMeng Gao & Naizhi Hu & XiaoLi Zhang & Yan ChengGang & ChengSheng Song & WenFeng Ma, . "The mechanism of N-carbamylglutamate promoting arginine synthesis and its application in pig production: A review," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 0.
    • Handle: RePEc:caa:jnlcjs:v:preprint:id:87-2025-cjas
    DOI: 10.17221/87/2025-CJAS
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