IDEAS home Printed from https://ideas.repec.org/a/caa/jnlcjs/v70y2025i7id43-2025-cjas.html
   My bibliography  Save this article

Effects of BRCA1 and TLR1 SNPs on milk production performance and somatic cell score in Holstein, Simmental and crossbred Holstein cattle

Author

Listed:
  • Maja Maurić Maljković

    (Department of Animal Breeding and Livestock Production, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia)

  • Tomislav Mašek

    (Department of Animal Nutrition and Dietetics, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia)

  • Marija Špehar

    (Croatian Agency for Agriculture and Food, Zagreb, Croatia)

  • Kristina Starčević

    (Department of Chemistry and Biochemistry, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia)

Abstract

Mastitis is a complex, common and economically problematic issue in dairy cattle production. In this study, breast cancer 1 (BRCA1) and toll-like receptor 1 (TLR1) genes were taken as candidate genes for mastitis resistance. This study investigated whether BRCA1 and TLR1 genes were associated with milk production traits (daily milk yield, fat, and protein content) and somatic cell score (SCS). A total of 105 cows (25 Holstein, 48 Simmental, and 32 crossbred Holstein) were genotyped using the PCR-RFLP method. Cows with the BRCA1 c.46126G>T GG genotype had significantly lower SCS than the other genotypes. The TLR1 g.60438363C>T SNP influenced the protein content in all cows, with genotype CC having a higher content than TC. The same SNP in the Simmental breed showed that cows with the CC genotype had significantly higher SCS than the heterozygote. Cows with the GG genotype of TLR1 g.60437324A>G had significantly lower SCS and higher fat and protein content than the heterozygote. The results of this study indicate that BRCA1 c.46126G>T and TLR1 g.60437324A>G SNPs could be useful for improving mastitis resistance in dairy cattle through marker-assisted selection.

Suggested Citation

  • Maja Maurić Maljković & Tomislav Mašek & Marija Špehar & Kristina Starčević, 2025. "Effects of BRCA1 and TLR1 SNPs on milk production performance and somatic cell score in Holstein, Simmental and crossbred Holstein cattle," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 70(7), pages 267-275.
    • Handle: RePEc:caa:jnlcjs:v:70:y:2025:i:7:id:43-2025-cjas
    DOI: 10.17221/43/2025-CJAS
    as

    Download full text from publisher

    File URL: http://cjas.agriculturejournals.cz/doi/10.17221/43/2025-CJAS.html
    Download Restriction: free of charge
    File URL: http://cjas.agriculturejournals.cz/doi/10.17221/43/2025-CJAS.pdf
    Download Restriction: free of charge
    File URL: https://libkey.io/10.17221/43/2025-CJAS?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to

    for a different version of it.

    More about this item

    Keywords

    ;
    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:caa:jnlcjs:v:70:y:2025:i:7:id:43-2025-cjas. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Ivo Andrle (email available below). General contact details of provider: https://www.cazv.cz/en/home/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.