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Mesobiliverdin IXα-enriched microalgae feed improves gut health in weaned piglets under LPS challenge

Author

Listed:
  • Tz-Shian Liao

    (Department of Animal Science and Technology, National Taiwan University, Taipei City, Taiwan)

  • Pei-En Chang

    (Institute of Biotechnology, National Taiwan University, Taipei City, Taiwan)

  • Yi-Ting Chen

    (Department of Animal Science and Technology, National Taiwan University, Taipei City, Taiwan)

  • Ching-Yi Chen

    (Department of Animal Science and Technology, National Taiwan University, Taipei City, Taiwan)

  • Cheng-Wei Tom Chang

    (Department of Chemistry and Biochemistry, Utah State University, Logan, Utah, USA)

  • Jon YutakaTakemoto

    (Department of Biology, Utah State University, Logan, Utah, USA)

  • Yuan-Yu Lin

    (Department of Animal Science and Technology, National Taiwan University, Taipei City, Taiwan)

Abstract

This study aimed to evaluate the effect of mesobiliverdin IXα-enriched microalgae (MBV-SP) on growth, diarrhoea prevalence, intestinal morphology, antioxidant capacity, and inflammatory cytokines in lipopolysaccharide (LPS)-induced enteritis in weaned piglets. Seventy-two 28-day-old piglets were randomly divided into four groups: control (NC), LPS, tylosin, and MBV-SP, with saline/LPS (100 µg/kg) administered intraperitoneally on day 14. Results showed reduced mortality and diarrhoea rates in the tylosin + LPS and MBV-SP + LPS groups compared to the LPS group. Histological analysis revealed improved villus morphology and decreased crypt depth in the MBV-SP group. Catalase activity was notably higher in the MBV-SP group. Both tylosin and MBV-SP supplementation reduced pro-inflammatory cytokines, with MBV-SP exhibiting a more pronounced effect. In conclusion, MBV-SP mitigated diarrhoea, improved antioxidant capacity, and modulated inflammatory cytokines in weaned piglets with LPS-induced enteritis, highlighting its potential as a dietary supplement for the gut health in piglets.

Suggested Citation

  • Tz-Shian Liao & Pei-En Chang & Yi-Ting Chen & Ching-Yi Chen & Cheng-Wei Tom Chang & Jon YutakaTakemoto & Yuan-Yu Lin, 2025. "Mesobiliverdin IXα-enriched microalgae feed improves gut health in weaned piglets under LPS challenge," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 70(4), pages 139-146.
    • Handle: RePEc:caa:jnlcjs:v:70:y:2025:i:4:id:159-2024-cjas
    DOI: 10.17221/159/2024-CJAS
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