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Effects of vitamin D3 on expression of defensins, Toll-like receptors, and vitamin D receptor in liver, kidney, and spleen of Silky Fowl

Author

Listed:
  • S.M. Li

    (Institute of Animal Husbandry and Veterinary, Jiangxi Academy of Agricultural Science, Nanchang, P.R. China)

  • L.H. Ouyang

    (Institute of Animal Husbandry and Veterinary, Jiangxi Academy of Agricultural Science, Nanchang, P.R. China)

  • D.G. Zhou

    (College of Animal Science and Technology, Sichuan Agricultural University, Yaan, P.R. China)

Abstract

The expression of avian β-defensins (AvBDs), Toll-like receptors (TLRs), and vitamin D receptor (VDR) following in vivo vitamin D3 injection was studied. Healthy 90-day Silky Fowls were abdominally injected with vitamin D3 or untreated. Real-time PCR analyses revealed that injection of vitamin D3 significantly (P < 0.05) up-regulated the expression of TLRs (TLR2, TLR5), VDR, AvBDs (AVBD-6, GAL-1), and 24-hydroxylase (CYP24A1) in the tissues (liver, spleen, and kidney) at various times 8-24 h post injection. These results suggest that expression of VDR, AvBDs, and TLRs seems to be induced by vitamin D3 and it was concluded that the tissues expressing TLRs and VDR respond to vitamin D3 and in turn upregulate these tissues cellular functions to synthesize AvBDs. Intraperitoneal injection of vitamin D3 likely resulted in enhancing the expression of AvBDs, TLRs, and VDR, which providedinsight into factors important for the control of the innateimmune response in the chickens.

Suggested Citation

  • S.M. Li & L.H. Ouyang & D.G. Zhou, 2013. "Effects of vitamin D3 on expression of defensins, Toll-like receptors, and vitamin D receptor in liver, kidney, and spleen of Silky Fowl," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 58(1), pages 1-7.
    • Handle: RePEc:caa:jnlcjs:v:58:y:2013:i:1:id:6519-cjas
    DOI: 10.17221/6519-CJAS
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    References listed on IDEAS

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    1. M. Sezer & S. Tarhan, 2005. "Model parameters of growth curves of three meat-type lines of Japanese quail," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 50(1), pages 22-30.
    2. K. Bílek & A. Knoll & A. Stratil & K. Svobodová & P. Horák & R. Bechyňová & M. Van Poucke & L.J. Peelman, 2008. "Analysis of mRNA expression of CNN3, DCN, FBN2, POSTN, SPARC and YWHAQ genes in porcine foetal and adult skeletal muscles," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 53(5), pages 181-186.
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    More about this item

    Keywords

    vitamin D3; induction; chicken; avian β -defensins; real-time PCR;
    All these keywords.

    JEL classification:

    • D3 - Microeconomics - - Distribution

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