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Sex reversed chicks (Gallus domesticus) hatched from eggs treated with aromatase inhibitor YM511

Author

Listed:
  • P. Trefil

    (BIOPHARM, Research Institute of Biopharmacy and Veterinary Drugs, Jílové near Prague, Czech Republic)

  • A. Mičáková

    (BIOPHARM, Research Institute of Biopharmacy and Veterinary Drugs, Jílové near Prague, Czech Republic)

  • J. Mucksová

    (BIOPHARM, Research Institute of Biopharmacy and Veterinary Drugs, Jílové near Prague, Czech Republic)

  • M. Poplštein

    (BIOPHARM, Research Institute of Biopharmacy and Veterinary Drugs, Jílové near Prague, Czech Republic)

  • J.-P. Brillard

    (INRA, Centre de Tours-Nouzilly, Station de Recherches Avicoles, Nouzilly, France)

  • P. Hodek

    (Department of Biochemistry, Charles University, Prague, Czech Republic)

Abstract

The objectives of this study were to assess post-hatch development of chickens treated in ovo with the aromatase inhibitor YM511. A total of 137 eggs coming from artificially inseminated hens were at first injected in the albumen with either DMSO alone (54 eggs injected, control group) or with DMSO + aromatase inhibitor (YM511, 1 mg/egg, 83 eggs injected, treated group) and then incubated under standard conditions. Out of the 24 chicks hatched in the treated group, 16 were genetic males (ZZ) and 8 were genetic females (ZW). By 26 weeks of age, secondary sex characteristics of females (cloaca, comb, wattles, song, feathers of hackle and tail) progressively transformed into a male phenotype. Using CT-scanner technology in these 8 birds, the presence of irregular testis-like masses positioned in the antero-ventral portion of the kidneys was observable, an indication that reproductive organs had also been affected by the treatment.

Suggested Citation

  • P. Trefil & A. Mičáková & J. Mucksová & M. Poplštein & J.-P. Brillard & P. Hodek, 2004. "Sex reversed chicks (Gallus domesticus) hatched from eggs treated with aromatase inhibitor YM511," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 49(12), pages 511-516.
    • Handle: RePEc:caa:jnlcjs:v:49:y:2004:i:12:id:4338-cjas
    DOI: 10.17221/4338-CJAS
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