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Optimisation of konjac glucomannan extraction conditions using response surface methodology

Author

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  • Jiajia Dai

    (School of Public Health, Wannan Medical College, Wuhu, P.R. China
    Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Wuhu, P.R. China)

  • Yuyan Zhou

    (Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Wuhu, P.R. China
    School of Pharmacy, Wannan Medical College, Wuhu, P.R. China)

  • Yike Han

    (School of Pharmacy, Wannan Medical College, Wuhu, P.R. China)

  • Banan Wei

    (School of Public Health, Wannan Medical College, Wuhu, P.R. China)

  • Jing Ou

    (School of Public Health, Wannan Medical College, Wuhu, P.R. China)

  • Xinyue Zhou

    (School of Pharmacy, Wannan Medical College, Wuhu, P.R. China)

  • Yujuan Chen

    (School of Public Health, Wannan Medical College, Wuhu, P.R. China)

  • Shushu Ding

    (School of Public Health, Wannan Medical College, Wuhu, P.R. China)

  • Guodong Wang

    (Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Wuhu, P.R. China
    School of Pharmacy, Wannan Medical College, Wuhu, P.R. China)

  • Donglin Zhang

    (School of Stomatology, Wannan Medical College, Wuhu, P.R. China)

Abstract

Konjac glucomannan (KGM), derived from konjac tubers, is a novel functional plant polysaccharide that plays a significant role in antioxidant activity, anti-tumour effects and blood glucose regulation. This study aimed to develop an optimal extraction method for KGM. The extraction yield of KGM was surveyed quantitatively analysed using a response surface central composite design (CCD) to maximise the yield. A quadratic regression model was created to illustrate the interactions between the factors influencing KGM extraction yield. The findings indicated that the effects of extraction temperature and the liquid-to-solid ratio had a greater impact on the extraction yield of KGM than the extraction time and extraction frequency. The optimal extraction conditions for KGM were determined to be an extraction temperature of 100 °C, an extraction time of 2 h, an extraction frequency of 2, and a liquid-to-solid ratio of 113 : 1. Under these optimal conditions, the extraction yield of KGM reached 15.31%.

Suggested Citation

  • Jiajia Dai & Yuyan Zhou & Yike Han & Banan Wei & Jing Ou & Xinyue Zhou & Yujuan Chen & Shushu Ding & Guodong Wang & Donglin Zhang, . "Optimisation of konjac glucomannan extraction conditions using response surface methodology," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 0.
    • Handle: RePEc:caa:jnlcjf:v:preprint:id:177-2025-cjfs
    DOI: 10.17221/177/2025-CJFS
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