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Transmission Disequilibrium Test Power and Sample Size in the Presence of Locus Heterogeneity

Author

Listed:
  • Chen Chuanwen

    (Rutgers University)

  • Yang Guang

    (Rutgers University)

  • Buyske Steven

    (Rutgers University)

  • Matise Tara

    (Rutgers University)

  • Finch Stephen J

    (Stony Brook University)

  • Gordon Derek

    (Rutgers University)

Abstract

Locus heterogeneity is one of the most important issues in gene mapping and can cause significant reductions in statistical power for gene mapping, yet no research to date has provided power and sample size calculations for family-based association methods in the presence of locus heterogeneity. The purpose of this research is three-fold: (i) to provide an analytic solution to the incorporation of locus heterogeneity into power and sample size calculations for the TDT statistic; (ii) to verify our analytic solution with simulations; and (iii) to study how different factors affect sample size requirement for the TDT in the presence of locus heterogeneity.

Suggested Citation

  • Chen Chuanwen & Yang Guang & Buyske Steven & Matise Tara & Finch Stephen J & Gordon Derek, 2009. "Transmission Disequilibrium Test Power and Sample Size in the Presence of Locus Heterogeneity," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 8(1), pages 1-16, October.
    • Handle: RePEc:bpj:sagmbi:v:8:y:2009:i:1:n:44
    DOI: 10.2202/1544-6115.1501
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