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Testing of Chromosomal Clumping of Gene Properties

Author

Listed:
  • Fernandez-Ricaud Luciano

    (University of Gothenburg)

  • Dalevi Daniel

    (Chalmers University of Technology and University of Gothenburg)

  • Blomberg Anders

    (University of Gothenburg)

  • Nerman Olle

    (Chalmers University of Technology and University of Gothenburg)

Abstract

Clumping of gene properties like expression or mutant phenotypes along chromosomes is commonly detected using completely random null-models where their location is equally likely across the chromosomes. Interpretation of statistical tests based on these assumptions may be misleading if dependencies exist that are unequal between chromosomes or in different chromosomal parts. One such regional dependency is the telomeric effect, observed in several studies of Saccharomyces cerevisiae, under which e.g. essential genes are less likely to reside near the chromosomal ends.

Suggested Citation

  • Fernandez-Ricaud Luciano & Dalevi Daniel & Blomberg Anders & Nerman Olle, 2009. "Testing of Chromosomal Clumping of Gene Properties," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 8(1), pages 1-27, February.
    • Handle: RePEc:bpj:sagmbi:v:8:y:2009:i:1:n:19
    DOI: 10.2202/1544-6115.1428
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