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The mid p-value in exact tests for Hardy-Weinberg equilibrium

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  • Graffelman Jan

    (Department of Statistics and Operations Research, Universitat Politècnica de Catalunya, Avinguda Diagonal 647, 08028 Barcelona, Spain)

  • Moreno Victor

    (Cancer Prevention Program, Catalan Institute of Oncology (ICO) Bellvitge Biomedical Research Institute (IDIBELL), Faculty of Medicine and CIBERESP, Department of Clinical Sciences, University of Barcelona (UB), Gran Via 199, 08908 L’Hospitalet del Llobregat (Barcelona), Spain)

Abstract

Objective: Exact tests for Hardy-Weinberg equilibrium are widely used in genetic association studies. We evaluate the mid p-value, unknown in the genetics literature, as an alternative for the standard p-value in the exact test.

Suggested Citation

  • Graffelman Jan & Moreno Victor, 2013. "The mid p-value in exact tests for Hardy-Weinberg equilibrium," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 12(4), pages 433-448, August.
    • Handle: RePEc:bpj:sagmbi:v:12:y:2013:i:4:p:433-448:n:2
    DOI: 10.1515/sagmb-2012-0039
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    References listed on IDEAS

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    1. Jon Wakefield, 2010. "Bayesian Methods for Examining Hardy–Weinberg Equilibrium," Biometrics, The International Biometric Society, vol. 66(1), pages 257-265, March.
    2. Attia John & Thakkinstian Ammarin & McElduff Patrick & Milne Elizabeth & Dawson Somer & Scott Rodney J & Klerk Nicholas de & Armstrong Bruce & Thompson John, 2010. "Detecting Genotyping Error Using Measures of Degree of Hardy-Weinberg Disequilibrium," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 9(1), pages 1-17, January.
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