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Estimation of Modified Concordance Ratio in Sib-Pairs: Effect of Consanguinity on the Risk of Congenital Heart Diseases

Author

Listed:
  • Shoukri Mohamed M

    (King Faisal Specialist Hospital and Research Centre)

  • Donner Allan

    (University of Western Ontario)

  • Dessouky Nadia Abdalla

    (King Faisal Specialist Hospital and Research Centre)

  • Subhani Shazia

    (King Faisal Specialist Hospital and Research Centre)

  • Al-Joufan Mansour

    (King Faisal Specialist Hospital and Research Centre)

  • Al-Omrani Ahmed

    (King Faisal Specialist Hospital and Research Centre)

  • Al-Mohanna Futwan

    (King Faisal Specialist Hospital and Research Centre)

  • Al Halees Zohair Y

    (King Faisal Specialist Hospital and Research Centre)

Abstract

Family studies are widely used for research into genetic and environmental influences on human traits. In this paper, we establish statistical methodology for the estimation of a new measure of sib similarity with respect to dichotomous traits measured on each member of within family sib-pair. We call this parameter "excess risk." For inference problems involving a single sample, we construct a large sample confidence interval on the concerned parameter. It has long been suspected that consanguinity is a risk factor for many genetic defects. Therefore, we establish a procedure to test the significance of the difference between excess risk parameters in a sample of consanguineous marriages and another sample of non-consanguineous marriages. We apply the methodology to data from a hospital-based congenital heart defects registry in Saudi Arabia, a population in which consanguinity is quite common.

Suggested Citation

  • Shoukri Mohamed M & Donner Allan & Dessouky Nadia Abdalla & Subhani Shazia & Al-Joufan Mansour & Al-Omrani Ahmed & Al-Mohanna Futwan & Al Halees Zohair Y, 2010. "Estimation of Modified Concordance Ratio in Sib-Pairs: Effect of Consanguinity on the Risk of Congenital Heart Diseases," The International Journal of Biostatistics, De Gruyter, vol. 6(1), pages 1-23, January.
    • Handle: RePEc:bpj:ijbist:v:6:y:2010:i:1:n:3
    DOI: 10.2202/1557-4679.1216
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