Comparison of Estimators for Measures of Linkage Disequilibrium
The measurement of biallelic pair-wise association called linkage disequilibrium (LD) is an important issue in order to understand the genomic architecture. A plethora of measures of association in two by two tables have been proposed in the literature. Beside the problem of choosing an appropriate measure, the problem of their estimation has been neglected in the literature. It needs to be emphasized that the definition of a measure and the choice of an estimator function for it are conceptually unrelated tasks.In this paper, we compare the performance of various estimators for the three popular LD measures D', r and Y in a simulation study for small to moderate samples sizes (N
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Volume (Year): 6 (2010)
Issue (Month): 1 (January)
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