IDEAS home Printed from https://ideas.repec.org/a/bpj/ijbist/v13y2017i1p16n8.html
   My bibliography  Save this article

Median Analysis of Repeated Measures Associated with Recurrent Events in Presence of Terminal Event

Author

Listed:
  • Sundaram Rajeshwari

    (Division of Intramural Population Health Research, National Institute of Child Health and Human Development, Rm 3232 6710B Rockledge Dr, Bethesda, MD20892-2425, USA)

  • Ma Ling

    (Division of Intramural Population Health Research, National Institute of Child Health and Human Development, Rm 3232 6710B Rockledge Dr, Bethesda, MD 20892-2425, USA)

  • Ghoshal Subhashis

    (Department of Statistics, North Carolina State University, Raleigh, NC, USA)

Abstract

Recurrent events are often encountered in medical follow up studies. In addition, such recurrences have other quantities associated with them that are of considerable interest, for instance medical costs of the repeated hospitalizations and tumor size in cancer recurrences. These processes can be viewed as point processes, i.e. processes with arbitrary positive jump at each recurrence. An analysis of the mean function for such point processes have been proposed in the literature. However, such point processes are often skewed, leading to median as a more appropriate measure than the mean. Furthermore, the analysis of recurrent event data is often complicated by the presence of death. We propose a semiparametric model for assessing the effect of covariates on the quantiles of the point processes. We investigate both the finite sample as well as the large sample properties of the proposed estimators. We conclude with a real data analysis of the medical cost associated with the treatment of ovarian cancer.

Suggested Citation

  • Sundaram Rajeshwari & Ma Ling & Ghoshal Subhashis, 2017. "Median Analysis of Repeated Measures Associated with Recurrent Events in Presence of Terminal Event," The International Journal of Biostatistics, De Gruyter, vol. 13(1), pages 1-16, May.
    • Handle: RePEc:bpj:ijbist:v:13:y:2017:i:1:p:16:n:8
    DOI: 10.1515/ijb-2016-0057
    as

    Download full text from publisher

    File URL: https://doi.org/10.1515/ijb-2016-0057
    Download Restriction: For access to full text, subscription to the journal or payment for the individual article is required.
    File URL: https://libkey.io/10.1515/ijb-2016-0057?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. D. Y. Lin, 2000. "Proportional Means Regression for Censored Medical Costs," Biometrics, The International Biometric Society, vol. 56(3), pages 775-778, September.
    2. Yining Ye & John D. Kalbfleisch & Douglas E. Schaubel, 2007. "Semiparametric Analysis of Correlated Recurrent and Terminal Events," Biometrics, The International Biometric Society, vol. 63(1), pages 78-87, March.
    3. Chiung-Yu Huang & Mei-Cheng Wang, 2004. "Joint Modeling and Estimation for Recurrent Event Processes and Failure Time Data," Journal of the American Statistical Association, American Statistical Association, vol. 99, pages 1153-1165, December.
    4. Lei Liu & Xuelin Huang & John O'Quigley, 2008. "Analysis of Longitudinal Data in the Presence of Informative Observational Times and a Dependent Terminal Event, with Application to Medical Cost Data," Biometrics, The International Biometric Society, vol. 64(3), pages 950-958, September.
    5. Jianguo Sun & Xingwei Tong & Xin He, 2007. "Regression Analysis of Panel Count Data with Dependent Observation Times," Biometrics, The International Biometric Society, vol. 63(4), pages 1053-1059, December.
    6. Debashis Ghosh & D. Y. Lin, 2003. "Semiparametric Analysis of Recurrent Events Data in the Presence of Dependent Censoring," Biometrics, The International Biometric Society, vol. 59(4), pages 877-885, December.
    7. D. Y. Lin & L. J. Wei & I. Yang & Z. Ying, 2000. "Semiparametric regression for the mean and rate functions of recurrent events," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 62(4), pages 711-730.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Miao Han & Liuquan Sun & Yutao Liu & Jun Zhu, 2018. "Joint analysis of recurrent event data with additive–multiplicative hazards model for the terminal event time," Metrika: International Journal for Theoretical and Applied Statistics, Springer, vol. 81(5), pages 523-547, July.
    2. C.-Y. Huang & J. Qin & M.-C. Wang, 2010. "Semiparametric Analysis for Recurrent Event Data with Time-Dependent Covariates and Informative Censoring," Biometrics, The International Biometric Society, vol. 66(1), pages 39-49, March.
    3. Qing Cai & Mei‐Cheng Wang & Kwun Chuen Gary Chan, 2017. "Joint modeling of longitudinal, recurrent events and failure time data for survivor's population," Biometrics, The International Biometric Society, vol. 73(4), pages 1150-1160, December.
    4. Qing Pan & Douglas E. Schaubel, 2009. "Flexible Estimation of Differences in Treatment-Specific Recurrent Event Means in the Presence of a Terminating Event," Biometrics, The International Biometric Society, vol. 65(3), pages 753-761, September.
    5. Gongjun Xu & Sy Han Chiou & Chiung-Yu Huang & Mei-Cheng Wang & Jun Yan, 2017. "Joint Scale-Change Models for Recurrent Events and Failure Time," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 112(518), pages 794-805, April.
    6. Jie Zhou & Haixiang Zhang & Liuquan Sun & Jianguo Sun, 2017. "Joint analysis of panel count data with an informative observation process and a dependent terminal event," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(4), pages 560-584, October.
    7. Xingqiu Zhao & Jie Zhou & Liuquan Sun, 2011. "Semiparametric Transformation Models with Time-Varying Coefficients for Recurrent and Terminal Events," Biometrics, The International Biometric Society, vol. 67(2), pages 404-414, June.
    8. Xiaoyu Wang & Liuquan Sun, 2023. "Joint modeling of generalized scale-change models for recurrent event and failure time data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(1), pages 1-33, January.
    9. Kwun Chuen Gary Chan & Mei-Cheng Wang, 2017. "Semiparametric Modeling and Estimation of the Terminal Behavior of Recurrent Marker Processes Before Failure Events," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 112(517), pages 351-362, January.
    10. Xiaowei Sun & Jieli Ding & Liuquan Sun, 2020. "A semiparametric additive rates model for the weighted composite endpoint of recurrent and terminal events," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(3), pages 471-492, July.
    11. Jin-Jian Hsieh & A. Adam Ding & Weijing Wang, 2011. "Regression Analysis for Recurrent Events Data under Dependent Censoring," Biometrics, The International Biometric Society, vol. 67(3), pages 719-729, September.
    12. Tianmeng Lyu & Björn Bornkamp & Guenther Mueller‐Velten & Heinz Schmidli, 2023. "Bayesian inference for a principal stratum estimand on recurrent events truncated by death," Biometrics, The International Biometric Society, vol. 79(4), pages 3792-3802, December.
    13. Laura M. Yee & Kwun Chuen Gary Chan, 2017. "Nonparametric inference for the joint distribution of recurrent marked variables and recurrent survival time," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(2), pages 207-222, April.
    14. Russell T. Shinohara & Yifei Sun & Mei-Cheng Wang, 2018. "Alternating event processes during lifetimes: population dynamics and statistical inference," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 24(1), pages 110-125, January.
    15. Yassin Mazroui & Audrey Mauguen & Simone Mathoulin-Pélissier & Gaetan MacGrogan & Véronique Brouste & Virginie Rondeau, 2016. "Time-varying coefficients in a multivariate frailty model: Application to breast cancer recurrences of several types and death," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 22(2), pages 191-215, April.
    16. Tianyu Zhan & Douglas E. Schaubel, 2019. "Semiparametric temporal process regression of survival-out-of-hospital," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 25(2), pages 322-340, April.
    17. Zhao, Xingqiu & Tong, Xingwei, 2011. "Semiparametric regression analysis of panel count data with informative observation times," Computational Statistics & Data Analysis, Elsevier, vol. 55(1), pages 291-300, January.
    18. P. G. Sankaran & P. Anisha, 2011. "Shared frailty model for recurrent event data with multiple causes," Journal of Applied Statistics, Taylor & Francis Journals, vol. 38(12), pages 2859-2868, February.
    19. Sehee Kim & Douglas E. Schaubel & Keith P. McCullough, 2018. "A C†index for recurrent event data: Application to hospitalizations among dialysis patients," Biometrics, The International Biometric Society, vol. 74(2), pages 734-743, June.
    20. Dongxiao Han & Xiaogang Su & Liuquan Sun & Zhou Zhang & Lei Liu, 2020. "Variable selection in joint frailty models of recurrent and terminal events," Biometrics, The International Biometric Society, vol. 76(4), pages 1330-1339, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bpj:ijbist:v:13:y:2017:i:1:p:16:n:8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Peter Golla (email available below). General contact details of provider: https://www.degruyter.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.