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A new ‘biased coin design’ for the sequential allocation of two treatments

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  • Alessandro Baldi Antognini
  • Alessandra Giovagnoli

Abstract

Summary. Efron's biased coin design is a well‐known randomization technique that helps to neutralize selection bias in sequential clinical trials for comparing treatments, while keeping the experiment fairly balanced. Extensions of the biased coin design have been proposed by several researchers who have focused mainly on the large sample properties of their designs. We modify Efron's procedure by introducing an adjustable biased coin design, which is more flexible than his. We compare it with other existing coin designs; in terms of balance and lack of predictability, its performance for small samples appears in many cases to be an improvement with respect to the other sequential randomized allocation procedures.

Suggested Citation

  • Alessandro Baldi Antognini & Alessandra Giovagnoli, 2004. "A new ‘biased coin design’ for the sequential allocation of two treatments," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 53(4), pages 651-664, November.
    • Handle: RePEc:bla:jorssc:v:53:y:2004:i:4:p:651-664
    DOI: 10.1111/j.1467-9876.2004.00436.x
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