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How Pharmaceutical Innovation Benefits From Spatial Aggregation: A Perspective Based on R&D Cooperation Networks

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  • Fusen Zhao
  • Jianting Fan

Abstract

This paper empirically analyzes the relationship between pharmaceutical industry agglomeration and enterprise innovation based on drug registration application data and pharmaceutical enterprise data in China, and explores the mechanism of the role of agglomeration in influencing innovation from a perspective of research and development (R&D) cooperation networks. It was found that the spatial agglomeration of pharmaceutical firms significantly enhanced innovation and that agglomeration contributed to innovation through three transmission pathways of R&D cooperation networks, which were whether firms were in the network, their location in the network, and the diversity of their partners in the network. The further discussion shows that there is significant regional heterogeneity in the transmission mechanism of pharmaceutical industry agglomeration through R&D cooperation networks and thus affects innovation. The results of the study provide useful insights into how to take advantage of agglomeration and further understand the relationship between agglomeration and innovation.

Suggested Citation

  • Fusen Zhao & Jianting Fan, 2025. "How Pharmaceutical Innovation Benefits From Spatial Aggregation: A Perspective Based on R&D Cooperation Networks," Growth and Change, Wiley Blackwell, vol. 56(3), September.
  • Handle: RePEc:bla:growch:v:56:y:2025:i:3:n:e70038
    DOI: 10.1111/grow.70038
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    1. Anderson Galvão & Carla Mascarenhas & Carla Marques, 2023. "Knowledge spillovers between universities and companies of low-density territories," Knowledge Management Research & Practice, Taylor & Francis Journals, vol. 21(1), pages 51-64, January.
    2. Diodato, Dario & Neffke, Frank & O’Clery, Neave, 2018. "Why do industries coagglomerate? How Marshallian externalities differ by industry and have evolved over time," Journal of Urban Economics, Elsevier, vol. 106(C), pages 1-26.
    3. Ron A. Boschma & Anet B.R. Weterings, 2005. "The effect of regional differences on the performance of software firms in the Netherlands," Journal of Economic Geography, Oxford University Press, vol. 5(5), pages 567-588, October.
    4. Annekatrin Niebuhr & Jan Cornelius Peters & Alex Schmidke, 2020. "Spatial sorting of innovative firms and heterogeneous effects of agglomeration on innovation in Germany," The Journal of Technology Transfer, Springer, vol. 45(5), pages 1343-1375, October.
    5. Broekel, Tom & Fornahl, Dirk & Morrison, Andrea, 2015. "Another cluster premium: Innovation subsidies and R&D collaboration networks," Research Policy, Elsevier, vol. 44(8), pages 1431-1444.
    6. Vigdis Boasson & Alan MacPherson & Hyun-Han Shin, 2005. "Firm Value and Geographic Competitive Advantage: Evidence from the U.S. Pharmaceutical Industry," The Journal of Business, University of Chicago Press, vol. 78(6), pages 2465-2495, November.
    7. Jeremy Howells, 2012. "The geography of knowledge: never so close but never so far apart," Journal of Economic Geography, Oxford University Press, vol. 12(5), pages 1003-1020, September.
    8. Gilsing, V. & Nooteboom, B., 2004. "Density and strength of ties in innovation networks: an analysis of multimedia and biotechnology," Working Papers 04.16, Eindhoven Center for Innovation Studies.
    9. Nooteboom, B. & Gilsing, V.A., 2004. "Density And Strength Of Ties In Innovation Networks: A Competence And Governance View," ERIM Report Series Research in Management ERS-2004-005-ORG, Erasmus Research Institute of Management (ERIM), ERIM is the joint research institute of the Rotterdam School of Management, Erasmus University and the Erasmus School of Economics (ESE) at Erasmus University Rotterdam.
    10. Ron Boschma & Koen Frenken, 2011. "The emerging empirics of evolutionary economic geography," Journal of Economic Geography, Oxford University Press, vol. 11(2), pages 295-307, March.
    11. Laura Abramovsky & Helen Simpson, 2011. "Geographic proximity and firm--university innovation linkages: evidence from Great Britain," Journal of Economic Geography, Oxford University Press, vol. 11(6), pages 949-977, November.
    12. Claudia Fuentes & Gabriela Dutrénit, 2016. "Geographic proximity and university–industry interaction: the case of Mexico," The Journal of Technology Transfer, Springer, vol. 41(2), pages 329-348, April.
    13. Sam Tavassoli & Charlie Karlsson, 2018. "The role of regional context on innovation persistency of firms," Papers in Regional Science, Wiley Blackwell, vol. 97(4), pages 931-955, November.
    14. Ron Boschma & Ernest Miguelez & Rosina Moreno & Diego B. Ocampo-Corrales, 2023. "The Role of Relatedness and Unrelatedness for the Geography of Technological Breakthroughs in Europe," Economic Geography, Taylor & Francis Journals, vol. 99(2), pages 117-139, March.
    15. Rosalia Castellano & Gaetano Musella & Gennaro Punzo, 2024. "How Do Agglomeration Externalities and Workforce Skills Drive Innovation? Empirical Evidence from Italy," Journal of the Knowledge Economy, Springer;Portland International Center for Management of Engineering and Technology (PICMET), vol. 15(2), pages 6737-6760, June.
    16. Grover, Arti & Lall, Somik & Timmis, Jonathan, 2023. "Agglomeration economies in developing countries: A meta-analysis," Regional Science and Urban Economics, Elsevier, vol. 101(C).
    17. Carlo Corradini, 2022. "Social trust and new firm formation: a regional perspective," Small Business Economics, Springer, vol. 58(1), pages 169-184, January.
    18. Simon Alder & Lin Shao & Fabrizio Zilibotti, 2016. "Economic reforms and industrial policy in a panel of Chinese cities," Journal of Economic Growth, Springer, vol. 21(4), pages 305-349, December.
    19. Haichao Yu & Shangze Dai & Haiqian Ke, 2024. "Industrial collaborative agglomeration and green economic efficiency—Based on the intermediary effect of technical change," Growth and Change, Wiley Blackwell, vol. 55(2), June.
    20. Cristian Barra & Ornella Wanda Maietta & Roberto Zotti, 2019. "Academic excellence, local knowledge spillovers and innovation in Europe," Regional Studies, Taylor & Francis Journals, vol. 53(7), pages 1058-1069, July.
    21. Yi Huang & Marco Pagano & Ugo Panizza, 2020. "Local Crowding‐Out in China," Journal of Finance, American Finance Association, vol. 75(6), pages 2855-2898, December.
    22. Henri L.F. Groot & Jacques Poot & Martijn J. Smit, 2016. "Which Agglomeration Externalities Matter Most And Why?," Journal of Economic Surveys, Wiley Blackwell, vol. 30(4), pages 756-782, September.
    23. Keld Laursen & Toke Reichstein & Ammon Salter, 2011. "Exploring the Effect of Geographical Proximity and University Quality on University-Industry Collaboration in the United Kingdom," Regional Studies, Taylor & Francis Journals, vol. 45(4), pages 507-523.
    24. Seongsoo Jang & Jinwon Kim & Max von Zedtwitz, 2017. "The importance of spatial agglomeration in product innovation: A microgeography perspective," Post-Print hal-02004347, HAL.
    25. Andrzej Cieślik & Iryna Gauger & Jan Jakub Michałek, 2018. "Agglomeration externalities, competition and productivity: empirical evidence from firms located in Ukraine," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 60(1), pages 213-233, January.
    26. Audretsch, David B. & Belitski, Maksim, 2020. "The role of R&D and knowledge spillovers in innovation and productivity," European Economic Review, Elsevier, vol. 123(C).
    27. Azari, Mehdi & Kim, Hakkon & Kim, Jun Yeup & Ryu, Doojin, 2016. "The effect of agglomeration on the productivity of urban manufacturing sectors in a leading emerging economy," Economic Systems, Elsevier, vol. 40(3), pages 422-432.
    28. Mei Hsiu-Ching Ho & Even Yi-Wen Liu, 2016. "Network resource, regional cluster, and technical position," Knowledge Management Research & Practice, Taylor & Francis Journals, vol. 14(4), pages 502-513, November.
    29. Beaudry, Catherine & Schiffauerova, Andrea, 2009. "Who's right, Marshall or Jacobs? The localization versus urbanization debate," Research Policy, Elsevier, vol. 38(2), pages 318-337, March.
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