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Meta-analysis: Assocation between promoter hypermethylation of DAPK (Death-Associated Protein Kinase) and cervical cancer

Author

Listed:
  • Lao Duc Thuan

    (Ho Chi Minh City Open University, Vietnam)

  • Truong Kim Phuong

    (Ho Chi Minh City Open University, Vietnam)

Abstract

Purpose: Death-associated protein kinase (DAPK or DAPK1) is an important tumor suppressor protein that involved in the regulation of cell activities. The aberrant methylation of DAPK promoter has been reported in patients with cervical cancer. However, the association between of DAPK1 and cervical cancer was not always unification, in previous studies. Therefore, in current study, a meta-analysis was performed for association of between DAPK gene’s promoter hypermethylated and cervical cancer. Methods: A systematic literature analysis was conducted based on the previous studies published in PubMed, PubMed Central (NCBI), Google by using following keywords: cervical cancer, cervical carcinoma, Methylation, by the end of January, 2018. The association between DAPK promoter methylation and cervical cancer was evaluated by odds ratio (ORs) and 95% confidence intervals (CI). To evaluate the potential sources of heterogeneity, the meta-regression analysis and subgroup analysis were conducted. Results: A total of 21 case-control studies which relevant to the association between DAPK1 gene’s promoter methylation frequency and cervical cancer, that including 1600 cancer cases and 1011 control cases (non-cancerous cases). The analysis results indicated that the characteristic of candidate gene’s promoter methylation increased the cervical cancer risk through the calculation of OR value (OR = 21.25; 95% CI = 8.73 – 52.97; p

Suggested Citation

  • Lao Duc Thuan & Truong Kim Phuong, 2019. "Meta-analysis: Assocation between promoter hypermethylation of DAPK (Death-Associated Protein Kinase) and cervical cancer," HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY, vol. 9(1), pages 41-50.
    • Handle: RePEc:bjw:techen:v:9:y:2019:i:1:p:41-50
    DOI: 10.46223/HCMCOUJS.tech.en.9.1.350.2019
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    References listed on IDEAS

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    1. Fucheng Cai & Xiyue Xiao & Xun Niu & Yi Zhong, 2017. "Association between promoter methylation of DAPK gene and HNSCC: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-13, March.
    2. Antonella Agodi & Martina Barchitta & Annalisa Quattrocchi & Andrea Maugeri & Manlio Vinciguerra, 2015. "DAPK1 Promoter Methylation and Cervical Cancer Risk: A Systematic Review and a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-15, August.
    3. Boaz Inbal & Ofer Cohen & Sylvie Polak-Charcon & Juri Kopolovic & Ezra Vadai & Lea Eisenbach & Adi Kimchi, 1997. "DAP kinase links the control of apoptosis to metastasis," Nature, Nature, vol. 390(6656), pages 180-184, November.
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    More about this item

    Keywords

    cervical cancer; DAPK1; methylation; meta-analysis;
    All these keywords.

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