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The initial study of EBNA-2 polymorphisms in nasopharyngeal carcinoma in Vietnam

Author

Listed:
  • Ngo Dong Kha

    (University of Science, Vietnam National University Ho Chi Minh City, Vietnam)

  • Huynh Thi Mong Tuyen

    (Ho Chi Minh City Open University, Vietnam)

  • Lam Hong Ngoc

    (Ho Chi Minh City Open University, Vietnam)

  • Thieu Hong Hue

    (Ho Chi Minh City Open University, Vietnam)

  • Le Quang Anh Tuan

    (Ho Chi Minh City Open University, Vietnam)

  • Lao Duc Thuan

    (Ho Chi Minh City Open University, Vietnam)

  • Le Huyen Ai Thuy

    (Ho Chi Minh City Open University, Vietnam)

Abstract

Epstein-Barr virus (EBV) infection is the main cause of Nasopharyngeal Carcinoma (NPC). EBNA-2, one of the most important genes participating in the formation of NPC, also helps EBV evade an attack on the immune system. EBNA-2 has 4 variants including E2-A, E2-B, E2-C and E-2D, of which E2-A and E2-C are the characterized variants for NPC. This study aimed to evaluate the variations of EBNA-2 in NPC biopsy samples of Vietnamese patients. This initial study used 10 biopsy samples, which were positively confirmed to NPC, collected from Cho Ray Hospital. Nested PCR – nucleotide sequencing was applied to analyze the variants of EBNA-2. The results showed that 8 out of 10 samples, accounting for 80%, were positive to EBNA-2. Additionally, only two variants, E-2A and E-2C were detected in our study, in which, E2-A subtype was identified as the predominant subtype. These findings would provide initial data about potential contribution of EBNA-2 polymorphisms to etiology of NPC in Vietnamese population.

Suggested Citation

  • Ngo Dong Kha & Huynh Thi Mong Tuyen & Lam Hong Ngoc & Thieu Hong Hue & Le Quang Anh Tuan & Lao Duc Thuan & Le Huyen Ai Thuy, 2018. "The initial study of EBNA-2 polymorphisms in nasopharyngeal carcinoma in Vietnam," HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY, vol. 8(1), pages 60-67.
    • Handle: RePEc:bjw:techen:v:8:y:2018:i:1:p:60-67
    DOI: 10.46223/HCMCOUJS.tech.en.8.1.337.2018
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