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The effect of paraquat herbicide on In Vivo spermatogenesis in mice

Author

Listed:
  • Nguyen Nhut Vu

    (Ho Chi Minh City Open University, Vietnam)

  • Nguyen Thi Thuy Hang

    (Ho Chi Minh City Open University, Vietnam)

  • Nguyen Thi Bich Thao

    (Ho Chi Minh City Open University, Vietnam)

  • Trinh Huu Phuoc

    (Ho Chi Minh City Open University, Vietnam)

Abstract

Paraquat (PQ) herbicide (1,1-dimethyl 4,4’-bipiridillium) is the most widely used in agricultural area on more than 100 crops in about 100 countries. PQ is highly acutely toxic with an acute oral LD50 for rat of 157 mg/kg. For aims to evaluate the toxic effects of low concentration of Paraquat on mouse spermatogenesis, mice (5 groups, n =7) were inter-dermal injected to the scrotal sac with the dose of PQ with four concentration as T1 (10 mg/kg), T2 (15mg/kg), T3 (20 mg/kg), T4 (25 mg/kg) and a control group with PBS treated. The evaluation of spermatogenesis were carried out by behavioral changes observation, weight body assessments, sperm counting and histological testis HE stained. The results indicated that PQ has toxic effects on spermatogenesis, especially, in the dose of 25 mg/kg, PQ significantly effect on the structureof testis leads to the failure of sperm producing.

Suggested Citation

  • Nguyen Nhut Vu & Nguyen Thi Thuy Hang & Nguyen Thi Bich Thao & Trinh Huu Phuoc, 2015. "The effect of paraquat herbicide on In Vivo spermatogenesis in mice," HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY, vol. 5(1), pages 3-7.
    • Handle: RePEc:bjw:techen:v:5:y:2015:i:1:p:3-7
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