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Comparison of Prevalence of Micronuclei in Oral Exfoliated Cells Among Tobacco and Non-Tobacco Users

Author

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  • Olatunji, T. K

    (Veterinary Pathology Division,National Veterinary Research Institute,Vom, Nigeria \ Medical Laboratory Science Department, Atiba University, Oyo, Oyo State.)

  • Oni, S.A

    (Medical Laboratory Science Department, Atiba University, Oyo, Oyo State.)

  • Omojoyegbe, O.R

    (Lagos State University Teaching Hospital, Ikeja, Lagos State.)

  • Farinloye, I.O

    (University College Hospital, Ibadan, Nigeria.)

  • Adetona, A.E

    (College of Medicine, Lead City University, Ibadan, Nigeria.)

Abstract

Micronuclei serves as biomarkers of genotoxic damage and are indicative of chromosomal instability, which is linked to an increased risk of oral cancer. This study aims to compare the prevalence of micronuclei in oral exfoliated cells among tobacco users and non-tobacco users. Two groups are used, where 100 tobacco users are the test group and 50 non-tobacco users are for the control group. Oral exfoliated cells obtained via cytological smears from the buccal mucosa. The smear was placed on a cleaned slide. Papanicolaou (Pap) staining techniques were used to identify and quantify micronuclei under a light microscope. Data were analyzed using SPSS statistical software. There was a statistically significant association between tobacco use and the presence of micronuclei in oral exfoliated cells (χ²(1) = 120.93, p

Suggested Citation

  • Olatunji, T. K & Oni, S.A & Omojoyegbe, O.R & Farinloye, I.O & Adetona, A.E, 2026. "Comparison of Prevalence of Micronuclei in Oral Exfoliated Cells Among Tobacco and Non-Tobacco Users," International Journal of Research and Innovation in Applied Science, International Journal of Research and Innovation in Applied Science (IJRIAS), vol. 11(6), pages 1486-1493, June.
    • Handle: RePEc:bjf:journl:v:11:y:2026:i:6:p:1486-1493
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