IDEAS home Printed from https://ideas.repec.org/a/bjf/journl/v10y2025i6p1885-1891.html
   My bibliography  Save this article

Potential of Muntingia Calabura L. Leaf Extract Cream on the Late Remodeling Phase of Wound Healing in Diabetic Rats (Rattus Norvegicus)

Author

Listed:
  • Muhammad Nur Salim

    (Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh, Indonesia)

  • Siti Aisyah

    (Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh, Indonesia)

  • Dian Masyitha

    (Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh, Indonesia)

  • Rumi Sahara Zamzami

    (Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh, Indonesia)

  • Betrianis

    (Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh, Indonesia)

Abstract

Wound healing is a complex biological mechanism of the body that repairs damaged tissue by involving various cellular activities. This study aimed to determine the effectiveness of Muntingia calabura L. leaf extract cream to accelerate incision wound healing on day 21 in white rats (Rattus norvegicus) with diabetes mellitus. This experiment used 12 male white rats weighing 150-200 g and 2-3 months old, induced by a single dose of streptozotocin. The incision was made on the paravertebral area along 2 cm and a depth of 2 mm. Wound therapy was given twice a day for 21 days, P1 was given cream base and distilled water , P2 was given 0.1% silver sulfadiazine cream and metformin 4, 5 mg/k g weight, P3 and P4 were given 5% and 15% Muntingia calabura L. leaf extract cream with oral extract 450 mg/k g body weight. ANOVA test results showed a significant effect (P

Suggested Citation

  • Muhammad Nur Salim & Siti Aisyah & Dian Masyitha & Rumi Sahara Zamzami & Betrianis, 2025. "Potential of Muntingia Calabura L. Leaf Extract Cream on the Late Remodeling Phase of Wound Healing in Diabetic Rats (Rattus Norvegicus)," International Journal of Research and Innovation in Applied Science, International Journal of Research and Innovation in Applied Science (IJRIAS), vol. 10(6), pages 1885-1891, June.
    • Handle: RePEc:bjf:journl:v:10:y:2025:i:6:p:1885-1891
    as

    Download full text from publisher

    File URL: https://www.rsisinternational.org/journals/ijrias/digital-library/volume-10-issue-6/1885-1891.pdf
    Download Restriction: no
    File URL: https://rsisinternational.org/journals/ijrias/articles/potential-of-muntingia-calabura-l-leaf-extract-cream-on-the-late-remodeling-phase-of-wound-healing-in-diabetic-rats-rattus-norvegicus/
    Download Restriction: no
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bjf:journl:v:10:y:2025:i:6:p:1885-1891. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Dr. Renu Malsaria (email available below). General contact details of provider: https://rsisinternational.org/journals/ijrias/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.