Synthesis And Antimicrobial Study of Fe (Ii) Complex of Schiff Base Derived From 4- Acyl Antipyrine and Substituted Aniline

The incidence of drug- resistant microbial infections is a growing concern worldwide, necessitating the development of novel antimicrobial agents that would break barrier of resistance, guarantee safety and potency of pharmaceutical products. The chemical synthesis and antimicrobial studies of Iron (II) complexes of Schiff base derived from acetyl chloride antipyrine (4-acyl antipyrine) were carried out using substituted aniline (2- hydroxylaniline) was one such attempts of development of new molecular compounds capable of breaking barrier of resistance. The primary ligand, Schiff base ligand and their metal complex was characterized using spectroscopic techniques ranging from IR, UV-Vis, GCMS. The melting point, molar conductivity, elemental composition was determined. Interestingly, all the synthesized compounds were obtained in good yield (76%-86%). The molecular ion peaks (M+) indicating the molecular weight of the synthesized ligand and metal complex were detected using the various fragments produced by the ligands and metal complexes based on their mass to charge ratio obtained from GC-MS Spectra. Octahedral geometry was observed for Fe (II) complex. The IR absorption showed characteristic behaviour in the sense that the v(C=N) found in SLOA and the metal complexes with frequency range of (1,582.90cm-1) indicate that imine group/Schiff base is formed. The absorption band assigned to C=O in the ligand and metal complexes are as follow 1,700.65cm-1 and 1,623.00cm-1 respectively. The Schiff base ligands SLOA (I,700.65cm-1) showed a notable shift to higher wavenumbers indicating increase C=O bond strength due to coordination with metal through its oxygen or electron withdrawal in the Schiff base framework. Metal complexes show C=O stretching shifted back to lower frequency value (1.633.54cm-1) suggesting co-ordination of oxygen to metal. The metal complexes demonstrated great antimicrobial efficiency on test organisms of both bacteria (Salmonella typhi, Escherichia coli, Staphylococcus aureus and Streptococcus pyogenes) and fungi (Candida albicans) more than the ligand due to lipophilicity of the chelated complexes which retarded their growth process. This study showed that synthesis and complexation have taken place and the knowledge gained will help to advance the course of bioinorganic and inorganic chemistry as well as incorporating ligands and metal complexes into antibiotic drugs production.