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Structure Predictions of Hydrolase from Thermobifida Fusca Using Computational Tools

Author

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  • Muhammad Yusuf Iqwan Bin Ramlee

    (Wellness Innovation Technology, Department of Chemical and Environmental Engineering (ChEE), Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia)

  • Nur `Ainun Mokhtar

    (Faculty of Pharmacy, Universiti Teknologi MARA Cawangan Pulau Pinang, Kampus Bertam, 13200 Kepala Batas, Pulau Pinang, MALAYSIA\Innovative Drug Development and Delivery Research Group (InDEED), Faculty of Pharmacy, Universiti Teknologi MARA, Cawangan Selangor, Kampus Puncak Alam, Bandar Puncak Alam, Selangor, MALAYSIA)

  • Nurulbahiyah Binti Ahmad Khairudin

    (Wellness Innovation Technology, Department of Chemical and Environmental Engineering (ChEE), Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia)

Abstract

The growing use of plastics like polyethylene terephthalate (PET) has led to increased pollution and a need for sustainable ways to break down these materials. One promising approach is using microbial enzymes through biocatalysis. This study focuses on a hydrolase enzyme from Thermobifida Fusca (T. Fusca), a heat-loving bacterium known for its stable and active properties at high temperatures, making it ideal for industrial use. The main aim of this research is to predict the 3D structure of this hydrolase using homology modelling and other computational methods. The predicted structure was carefully validated using structural assessment techniques such as the Ramachandran plot to ensure high accuracy and reliability. Sequence alignment analysis helped identify evolutionary traits and potential catalytic sites, offering insights into how the enzyme functions and interacts with PET and other substrates.

Suggested Citation

  • Muhammad Yusuf Iqwan Bin Ramlee & Nur `Ainun Mokhtar & Nurulbahiyah Binti Ahmad Khairudin, 2026. "Structure Predictions of Hydrolase from Thermobifida Fusca Using Computational Tools," International Journal of Latest Technology in Engineering, Management & Applied Science, RSIS International, vol. 15(7), pages 1077-1080, August.
    • Handle: RePEc:bjf:ijltem:v:15:y:2026:i:7:a:90
    DOI: 10.51583/IJLTEMAS.2026.150700085
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