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Antimutagenic, Antioxidant and Anti-inflammatory Evaluation of Selected Seed Oils: Potential Application for Skin Cancer Chemoprevention

Author

Listed:
  • Adebayo Masaudat A

    (Department of Biochemical Science, The Federal Polytechnic Ede, Nigeria.)

  • Adedosu O. T

    (Department of Biochemistry, Ladoke Akintola University of Technology Ogbomoso, Nigeria.)

  • Badmus J. A

    (Department of Biochemistry, Ladoke Akintola University of Technology Ogbomoso, Nigeria.)

  • Olagoke E. O

    (Department of Biochemistry, Ladoke Akintola University of Technology Ogbomoso, Nigeria.)

  • Babalola O.O

    (Department of Biochemistry, Ladoke Akintola University of Technology Ogbomoso, Nigeria.)

  • Akinboro A

    (Department of Chemical Sciences, Dominion University Ibadan, Nigeria.)

Abstract

Background: Skin cancer is a major global health concern driven by ultraviolet radiation (UVR)-induced DNA damage, oxidative stress, and chronic inflammation. Targeting these interconnected processes is critical for effective chemoprevention. This study aimed to evaluate the antimutagenic, antioxidant, and anti-inflammatory potential of selected seed oils (Citrullus lanatus, Cocos nucifera, and Vitellaria paradoxa) and to explore their relevance in mitigating key pathways involved in skin carcinogenesis. Methods: Seed oils were extracted using Soxhlet extraction and assessed using established in vitro assays. Antimutagenic activity was determined using the Ames test with -Ve-His-Salmonella typhimurium. Antioxidant capacity was evaluated via 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, hydroxyl radical scavenging, and lipid peroxidation inhibition assays. Anti-inflammatory activity was determined by protein denaturation and proteinase inhibition assays. All experiments were conducted in triplicate, and statistical significance was determined using one-way ANOVA at P

Suggested Citation

  • Adebayo Masaudat A & Adedosu O. T & Badmus J. A & Olagoke E. O & Babalola O.O & Akinboro A, 2026. "Antimutagenic, Antioxidant and Anti-inflammatory Evaluation of Selected Seed Oils: Potential Application for Skin Cancer Chemoprevention," International Journal of Latest Technology in Engineering, Management & Applied Science, RSIS International, vol. 15(7), pages 631-643, August.
    • Handle: RePEc:bjf:ijltem:v:15:y:2026:i:7:a:57
    DOI: 10.51583/IJLTEMAS.2026.150700052
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