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Hypoglycemic Property of Different Fractions of Crude Ethanol Extract of Azadirachta indica Leaves in Streptozotocin-induced Diabetic Rats

Author

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  • Obiajulu Christian Ezeigwe

    (Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria)

  • Chukwuemeka Obumneme Okpala

    (Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria)

  • Chidimma Stella-Maris Okeke

    (Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria)

  • Perpetua Chiamaka Amuzie

    (Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria)

  • Blessing Adaobi Okeke

    (Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria)

  • Chiemeka Princess-Dolorosa Ikechukwu

    (Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria)

  • Ejike Celestine Orji

    (Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria)

  • Naomi Ngozi Nnadi

    (Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria)

Abstract

Background: Azadirachta indica (AI) is used in the traditional management of diabetes in Nigeria. This study investigated the hypoglycemic potential of Azadirachta indica leaf fractions (AILF) in streptozotocin-induced diabetic male rats. Methods: Ethanol crude extract of AI leaf was fractionated with solvents of increasing order of polarity (n-hexane, chloroform, ethyl-acetate, and n-butanol). Phytochemical analysis was done using standard methods. Diabetes mellitus was induced in the rats intraperitoneally with 50mg/kg bodyweight of streptozotocin. Treatment with the AILF was done for a period of twenty-eight days to ascertain which of the AILF possess better hypoglycemic property. Fasting blood glucose levels were checked at one week intervals using One Touch Glucometer and Test Strips. Results: Bioactive compounds detected in moderate and trace amounts in the AILF include alkaloids, cyanogenic glycosides, flavonoids, phenols, saponin and tannins. Induction of diabetes caused a significant (p

Suggested Citation

  • Obiajulu Christian Ezeigwe & Chukwuemeka Obumneme Okpala & Chidimma Stella-Maris Okeke & Perpetua Chiamaka Amuzie & Blessing Adaobi Okeke & Chiemeka Princess-Dolorosa Ikechukwu & Ejike Celestine Orji , 2020. "Hypoglycemic Property of Different Fractions of Crude Ethanol Extract of Azadirachta indica Leaves in Streptozotocin-induced Diabetic Rats," International Journal of Research and Scientific Innovation, International Journal of Research and Scientific Innovation (IJRSI), vol. 7(6), pages 190-194, June.
    • Handle: RePEc:bjc:journl:v:7:y:2020:i:6:p:190-194
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