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Exploring the Anticancer Properties of Phytochemicals from Jatropha gossypiifolia

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  • Ajay Raj

    (Student (M. Pharm 4th Semester), Career Point university Kota, Rajasthan)

  • Prof. (Dr.) M.K. Gupta

    (Principal, School of Pharmacy, (Health and Allied Sciences) Career Point university Kota, Rajasthan)

Abstract

The present study aimed to isolate and evaluate bioactive compounds from Jatropha gossypiifolia through a series of extraction, fractionation, and chromatographic techniques. Various extraction methods followed by multiple liquid-liquid partitioning and compound isolation using preparative and column chromatography were employed. Phytochemical screening of the fractions revealed the presence of phytosterols, copper acetate, alkaloids, and proteins. A compound isolated from the chloroform fraction was further characterized using proton nuclear magnetic resonance (^1H NMR) spectroscopy. Antioxidant activity of the methanolic extract was assessed using the DPPH radical scavenging assay, which exhibited 37.50% scavenging activity, whereas the standard ascorbic acid showed 97.92%. Additionally, cytotoxicity was evaluated using the MTT assay on the MDA-MB-231 human breast cancer cell line, where the petroleum ether fraction demonstrated significant activity with 12 µg/mL concentration resulting in reduced cell viability. These findings indicate that Jatropha gossypiifolia possesses potent antioxidant and anticancer compounds, highlighting its potential in pharmaceutical applications.

Suggested Citation

  • Ajay Raj & Prof. (Dr.) M.K. Gupta, 2025. "Exploring the Anticancer Properties of Phytochemicals from Jatropha gossypiifolia," International Journal of Research and Scientific Innovation, International Journal of Research and Scientific Innovation (IJRSI), vol. 12(5), pages 26-32, May.
    • Handle: RePEc:bjc:journl:v:12:y:2025:i:5:p:26-32
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