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Advances on Quinoline Derivatives: A Review of Synthesis and Biological Activities

Author

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  • Emmanuel Chinedu Nnadi

    (Department of Science Laboratory Technology, University of Nigeria, Nsukka Department of Chemistry, University of Iowa, USA)

  • Vivian Ifeoma Okonkwo

    (Department of Science Laboratory Technology, University of Nigeria, Nsukka)

  • Chidinma Eucharia Ikwelle

    (Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka)

  • Faith Temitope Elijah

    (Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka)

  • Anulika Ruphina Phil-Mba

    (Department of Pharmacy, University of Nigeria, Nsukka)

  • Vivian Chinenye Odo

    (Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka)

  • Blessing Ginika Eke

    (Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka)

Abstract

Quinoline compounds and their derivatives have a vast distribution in nature coupled with their immense therapeutic potential. Due to the unfading therapeutic benefits of these compounds over the years, a lot of researchers are exploring the synthesis of various derivatives of quinoline which are screened for different therapeutic activities including, anti-malarial, anti-microbial, anti-inflammatory, anti-convulsant, anti-cancer anti-mycobacterial, cardio-protective, neuroprotective activity etc. This review highlights various advances in the synthetic routes and methodology for some quinoline derivatives including Friedlander modified metal-catalyzed reactions, Photo-induced oxidative annulation reaction, Microwave-assisted doebner reaction and their biological properties.

Suggested Citation

  • Emmanuel Chinedu Nnadi & Vivian Ifeoma Okonkwo & Chidinma Eucharia Ikwelle & Faith Temitope Elijah & Anulika Ruphina Phil-Mba & Vivian Chinenye Odo & Blessing Ginika Eke, 2025. "Advances on Quinoline Derivatives: A Review of Synthesis and Biological Activities," International Journal of Research and Scientific Innovation, International Journal of Research and Scientific Innovation (IJRSI), vol. 12(13), pages 2584-2610, August.
    • Handle: RePEc:bjc:journl:v:12:y:2025:i:13:p:2584-2610
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