IDEAS home Printed from https://ideas.repec.org/a/bjb/journl/v14y2025i6p5-9.html
   My bibliography  Save this article

Nutrigenetic Impact of PEMT Gene Polymorphism Rs7946 On Choline Metabolism and Its Role in Personalised Nutrition

Author

Listed:
  • Dr Shamya Reny

    (University of Cambridge School of Medicine, Cambridge, U)

Abstract

The PEMT (phosphatidylethanolamine N-methyltransferase) gene plays a critical role in the endogenous synthesis of phosphatidylcholine, an essential compound in lipid metabolism and liver health. The single nucleotide polymorphism (SNP) rs7946 (V175M) within the PEMT gene influences the enzymatic activity and structural stability, leading to altered choline metabolism. Individuals carrying Aallele exhibit reduced PEMT activity, predisposing themto non-alcoholic fatty liver disease (NAFLD), elevated homocysteine levels, and reproductive or cognitive risks under low choline diets. This impact is modulated by sex hormones, particularly oestrogen, rendering postmenopausal women more susceptible. This review summarises recent findings linking PEMT rs7946 variants with metabolic, hepatic, and psychological outcomes and explores gene diet interactions that informs genotype based nutritional recommendations. It also suggests tailored choline intake strategies based on genotype. We argue for the integration of PEMT screening in nutritional counselling, especially for vulnerable groups. Future nutrigenetics research is necessary to refine these guidelines and assess long-term impacts.

Suggested Citation

  • Dr Shamya Reny, 2025. "Nutrigenetic Impact of PEMT Gene Polymorphism Rs7946 On Choline Metabolism and Its Role in Personalised Nutrition," International Journal of Latest Technology in Engineering, Management & Applied Science, International Journal of Latest Technology in Engineering, Management & Applied Science (IJLTEMAS), vol. 14(6), pages 5-9, June.
    • Handle: RePEc:bjb:journl:v:14:y:2025:i:6:p:5-9
    as

    Download full text from publisher

    File URL: https://www.ijltemas.in/DigitalLibrary/Vol.14Issue6/5-9.pdf
    Download Restriction: no
    File URL: https://www.ijltemas.in/papers/volume-14-issue-6/5-9.html
    Download Restriction: no
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bjb:journl:v:14:y:2025:i:6:p:5-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Dr. Pawan Verma (email available below). General contact details of provider: https://www.ijltemas.in/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.