Takayasu Artiritis, Peyronie’s Disease and Dupuytren’s Disease: A Non-Fortuitous Association

Background: Peyronie’s disease (PD), Dupuytren’s disease (DD) and Ledderhose disease (LD) are three localized fibrosis. Its pathophysiology is still controversial. Many factors as genetic predisposition, trauma and inflammation could be related. These disorders are commonly associated to environmental factors, diabetes and microtrauma. Until now, there is not a study reporting an association between PD, DD and large vessel vasculitis particularly takayasu’s arteritis. Case Report: It is about a 52-year-old man weaned from smoking since 15 years, with a history of takayasu’s arteritis for 10 years. At the CT angiography, he had a stenosis of the left subclavian artery, left carotid artery and left renal artery with a functional right kidney. At the physical examination, the penis size was normal but curved and deviated to the right side with palpable nodules. A penile ultrasonography was performed showing hyeperchogenic thickening of the tunica albuginea. The upper limbs examination showed nodules in the palm, fourth and fifth fingers in two hands but more pronounced in the left hand, with contractures related to DD and absence pulses in the left subclavian, humeral and radial arteries. Conclusion: To the best of our knowledge, there are no studies or cases reporting the association between a vasculitis of large artery and DD and PD. The presence of a PD on an occluded renal artery and a DD on a stenosed left subclavian artery, could be explain this theory.