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Amelioration of Gentamicin Induced Dyslipidemia in Guinea Pigs by Curcumin and Rosemary

Author

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  • Munira Ammar Algridi

    (Department of Zoology, Faculty of Science, Alejelat, Zawia University, Libya)

  • Azab Elsayed Azab

    (Department of Zoology, Faculty of Science, Alejelat, Zawia University, Libya)

Abstract

The present study aimed to evaluate the effectiveness of curcumin, and Rosemary as a natural source of antioxidants to minimize the harmful effects of gentamicin induced dyslipidemia in Guinea pigs. Guinea pigs were divided into five groups. The first group (control) was injected intraperitoneal with saline. The 2nd group was injected intraperitoneal with gentamicin at a dose of 100 mg/kg body weight /day. The 3th , 4th , and 5th groups were injected intraperitoneal with gentamicin (100 mg/kg b. wt /day) concurrently with curcumin, rosemary, and curcumin with rosemary at the doses of 200 mg, 220 mg, and 200 mg with 220 mg /kg body weight /day respectively orally by gavage for 10 days. Blood samples were obtained for assessment of serum cholesterol, triglycerides, high density lipids, low density lipids, and very low density lipids concentrations. Gentamicin treatment induced dyslipidemia. Guinea pigs that injected intraperitonally with gentamicin at a dose of 100 mg/kg body weight daily for 10 days had significantly (p

Suggested Citation

  • Munira Ammar Algridi & Azab Elsayed Azab, 2017. "Amelioration of Gentamicin Induced Dyslipidemia in Guinea Pigs by Curcumin and Rosemary," Scientific Review, Academic Research Publishing Group, vol. 3(2), pages 6-16, 02-2017.
    • Handle: RePEc:arp:srarsr:2017:p:6-16
    DOI: arpgweb.com/?ic=journal&journal=10&info=aims
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