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Effects of Antibiotics on Haemostatic Parameters during Pregnancy

Author

Listed:
  • Amaechi R. A.

    (Haematology Unit, Department of Medical Laboratory Science, Ambrose Alli University, Ekpoma, Edo State, Nigeria)

  • Turay A. A.

    (Medical Microbiology Unit, Department of Medical Laboratory Science, Ambrose Alli University, Ekpoma, Edo State, Nigeria)

  • Okobi T. J.

    (Biology Department, Georgetown University, Washington D.C., USA)

  • Usoro E. R.

    (Department of Biomedical Sciences, Augusta University, Augusta Georgia, USA)

  • Ken-Iyevhobu B. A.

    (Department of Microbiology, Ambrose Alli University, Ekpoma, Edo State, Nigeria)

Abstract

An estimated 50,000 Nigerian women die each year from complications of pregnancy and childbirth, accounting for 10% of global estimates of pregnancy maternal death with about 2% resulting from drug induction. This cross-sectional study sets out to evaluate the Prothrombin time test (PT), activated partial thromboplastin time test (aPTT) Erythrocyte sedimentation rate (ESR), and Platelet count (PC) of pregnant women attending antenatal clinics at Oredo Health Centre in Benin City, Edo State. A total number of 130 subjects comprising 100 pregnant women and 30 non-pregnant women were recruited for the study. Prothrombin time (PT), Activated Partial Thromboplastin Time (APTT), Platelet count and Erythrocyte Sedimentation Rate (ESR) were studied using standard manual methods. The prothrombin time (sec) of the pregnant women 1st trimester (19.12±0.77b), 2nd trimester (19.90±1.02 b) and 3rd trimester (19.66±0.56 b), activated partial thromboplastin time (sec) 1st trimester (44.02±1.17 b), 2nd trimester (47.72±1.47 b) and 3rd trimester (45.88±1.10b), Erythrocyte sedimentation rate (mm/hr) 1st trimester (24.37±3.04 a), 2nd trimester (37.83±4.53 a) and 3rd trimester (43.25±5.24 a) and platelet count (X109/L) 1st trimester (248.29±23.18a), 2nd trimester (236.33±13.84 b) and 3rd trimester (239.10±16.07 a) were significantly higher than the prothrombin time (sec) 16.48±0.81 a, activated partial thromboplastin time (sec) 36.53±1.42 a, ESR (mm/hr) 29.83±4.14 a and platelet count (X109/L) 201±9.54 an of the non-pregnant women (p

Suggested Citation

  • Amaechi R. A. & Turay A. A. & Okobi T. J. & Usoro E. R. & Ken-Iyevhobu B. A., 2021. "Effects of Antibiotics on Haemostatic Parameters during Pregnancy," Journal of Biotechnology Research, Academic Research Publishing Group, vol. 7(3), pages 57-62, 07-2021.
    • Handle: RePEc:arp:rjbarp:2021:p:57-62
    DOI: 10.32861/jbr.73.57.62
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