IDEAS home Printed from https://ideas.repec.org/a/arp/rjbarp/2017p85-93.html
   My bibliography  Save this article

Genotoxic and Biochemica Effects of Consumption of Heavy Metal Contaminated Fish and Its Reversal Using Zinc Supplements in Rats

Author

Listed:
  • Bolawa O. E.

    (Department of Biochemistry, College of Medicine, University of Lagos, P.M.B 12003, Idi-Araba, Lagos State, Nigeria)

  • Ebuehi O. A. T.

    (Department of Biochemistry, College of Medicine, University of Lagos, P.M.B 12003, Idi-Araba, Lagos State, Nigeria)

Abstract

Introduction: Heavy metals such as lead, cadmium, chromium etc are environmental contaminants. They are also known today as human and animal carcinogens. Objectives: The aim of the study was to evaluate the genotoxic and biochemical effect of feeding rat with fish obtained from heavy metal contaminated water bodies in Lagos, Nigeria. Methods: DNA damage was investigated using DNA lading assay, while heavy metals and antioxidants were analyzed from fishes obtained from contaminated water bodies. Results: There was fragmentation of blood chromosomal DNA in rats fed with heavy metal contaminated fish, while in the control and zinc supplemented group, there was no fragmentation. Heavy metals were detected in the tissues and serum of exposed rat, while the activity of the serum catalase and reduced glutathione significantly decreased. Conclusion: The consumption of heavy metal contaminated fish resulted in DNA fragmentation and its deposition in the rat tissue. Zinc supplementation prevented the degradation of DNA and potentiated antioxidant activities.

Suggested Citation

  • Bolawa O. E. & Ebuehi O. A. T., 2017. "Genotoxic and Biochemica Effects of Consumption of Heavy Metal Contaminated Fish and Its Reversal Using Zinc Supplements in Rats," Journal of Biotechnology Research, Academic Research Publishing Group, vol. 3(10), pages 85-93, 10-2017.
    • Handle: RePEc:arp:rjbarp:2017:p:85-93
    DOI: arpgweb.com/?ic=journal&journal=16&info=aims
    as

    Download full text from publisher

    File URL: http://www.arpgweb.com/pdf-files/jbr3(10)85-93.pdf
    Download Restriction: no
    File URL: http://www.arpgweb.com/?ic=journal&journal=16&month=10-2017&issue=10&volume=3
    Download Restriction: no
    File URL: https://libkey.io/arpgweb.com/?ic=journal&journal=16&info=aims?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:arp:rjbarp:2017:p:85-93. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Managing Editor (email available below). General contact details of provider: http://arpgweb.com/index.php?ic=journal&journal=16&info=aims .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.