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Matrixmetalloproteinase-9 Genetic Variation with Cataract, Glaucoma and Retinoblastoma in a Senegalese Population

Author

Listed:
  • Matar Ciss

    (Genetic for Gestion of Population team (GENGESPOP), Department of Animal Biology, Faculty of sciences and Technics, Cheikh Anta Diop University, Dakar, Sénégal)

  • Ndéye Ndoumbé Guéye

    (Ophthalmology Department, Principal Hospital, Dakar, Senegal)

  • Fatimata Mbaye*

    (Genetic for Gestion of Population team (GENGESPOP), Department of Animal Biology, Faculty of sciences and Technics, Cheikh Anta Diop University, Dakar, Sénégal)

  • Paul A?da Ndoye

    (Ophthalmology Department, Aristide Le Dantec Hospital, Dakar, Senegal)

  • Chérif Dial

    (Anapathologic Department, Grand Yoff General Hospital, Dakar, Senegal)

  • Joseph Ndiaye

    (Ophthalmology Department, Aristide Le Dantec Hospital, Dakar, Senegal)

  • Mbacké Sembéne

    (Genetic for Gestion of Population team (GENGESPOP), Department of Animal Biology, Faculty of sciences and Technics, Cheikh Anta Diop University, Dakar, Sénégal)

Abstract

The Matrix metalloproteinase-9 is involved in several pathologies. Its strong presence in ocular pathologies explains our interest for its genetic variation in cataract, glaucoma and retinoblastoma in Senegal. MMP9 is highly polymorphic with cataract and glaucoma. 77 mutations were noted with 21 haplotypes for the entire population. The haplotype diversity Hd is 0.831 and the nucleotide diversity Pi is 0.016; k = 17.395. The polymorphism of the Matrix metalloproteinase-9 gene is associated with all three diseases and SNP 3918249 is found in both cataract and glaucoma.

Suggested Citation

  • Matar Ciss & Ndéye Ndoumbé Guéye & Fatimata Mbaye* & Paul A?da Ndoye & Chérif Dial & Joseph Ndiaye & Mbacké Sembéne, 2019. "Matrixmetalloproteinase-9 Genetic Variation with Cataract, Glaucoma and Retinoblastoma in a Senegalese Population," International Journal of Healthcare and Medical Sciences, Academic Research Publishing Group, vol. 5(10), pages 52-58, 10-2019.
    • Handle: RePEc:arp:ijohms:2019:p:52-58
    DOI: 10.32861/ijhms.510.52.58
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