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Impact of HIV-Infection on Serum Liver Enzymes: A Comparative Study among Anti-retroviral Therapy (ART) Naïve Patients, ART Follow-Up Patients, and HIV Sero-negative Controls

Author

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  • Agbecha

    (Department of Chemical Pathology, Federal Medical Centre, Makurdi, Nigeria)

  • Ikyernum J. A.

    (Department of Medical Microbiology, Virology Unit, Federal Medical Centre, Makurdi, Nigeria)

Abstract

Background of study: There is emerging evidence that human immunodeficiency virus (HIV) infection, even in the absence of anti-retroviral therapy (ART) toxicity and other cofactors, may have a direct impact on liver pathogenesis. Aim: Based on this premise, our study determined the impact of HIV infection on liver enzymes as markers of hepatic function. Methods: the case-control study comprised of a total of 60 participants (30 males and 30 females) aged 18-60 years. The study compared aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), cluster of differentiation (CD4+) cells among ART-naïve HIV patients (n=20), follow-up HIV patients who were on highly active ART (n=20) and apparently healthy controls (n=20). Results: a significant (P

Suggested Citation

  • Agbecha & Ikyernum J. A., 2018. "Impact of HIV-Infection on Serum Liver Enzymes: A Comparative Study among Anti-retroviral Therapy (ART) Naïve Patients, ART Follow-Up Patients, and HIV Sero-negative Controls," International Journal of Healthcare and Medical Sciences, Academic Research Publishing Group, vol. 4(12), pages 196-200, 12-2018.
    • Handle: RePEc:arp:ijohms:2018:p:196-200
    DOI: 10.32861/ijhms.412.196.200
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