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Rapid Access to Synthesis of Bisindole Derivatives Using 2-Morpholino Ethanesulphonic Acid

Author

Listed:
  • Rajendra P. Pawar

    (Department of Chemistry, Deogiri College, Station Road, Aurangabad-431 005, MS, India)

  • Devidas S. Bhagat

    (Department of Forensic Chemistry, Government Institute of Forensic Science, Aurangabad-431004 MS, India)

  • Suresh U. Shisodia

    (Department of Chemistry, Deogiri College, Station Road, Aurangabad-431 005, MS, India)

  • Hanuman D. Bhosale

    (Department of Chemistry, Deogiri College, Station Road, Aurangabad-431 005, MS, India)

  • Sudam S. Pandule

    (Department of Chemistry, Nowrosjee Wadia College, Bund Garden Road, Pune 411001, MS, India)

  • Pravin S. Kendrekar

    (Department of Chemistry and Directorate: Research Development, University of the Free State, Nelson Mandela Drive 205, Bloemfontein 9301, South Africa)

Abstract

The present work demonstrates easy and effective synthesis methodology for synthesis of bisindole derivatives in presence of protic organic acid 2-morpholino ethanesulphonic acid (MESA). 2-MESA is water soluble catalyst easy to extract and work-up for the synthesis of bisindole class of compounds. Catalyst is recovered and recycled by simple evaporation of water. Efficient aromatic electrophilic substitution of indoles (2 mmol) with aromatic aldehydes (1 mmol) equipped with various constituents were carried out employing a catalytic amount in ethanol to obtain bisindoles in good to excellent yields.

Suggested Citation

  • Rajendra P. Pawar & Devidas S. Bhagat & Suresh U. Shisodia & Hanuman D. Bhosale & Sudam S. Pandule & Pravin S. Kendrekar, 2016. "Rapid Access to Synthesis of Bisindole Derivatives Using 2-Morpholino Ethanesulphonic Acid," Academic Journal of Chemistry, Academic Research Publishing Group, vol. 1(1), pages 26-32, 10-2016.
    • Handle: RePEc:arp:ajcarp:2016:p:26-32
    DOI: arpgweb.com/?ic=journal&journal=20&info=aims
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