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Molecular Docking of Gnetin C and Transresveratrol of Melinjo Seeds (Gnetum Gnemon L.) Used as the Inhibitors of Breast Cancer Cells MCF-7

Author

Listed:
  • Kintan Nur Romadhona

    (Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia)

  • Nenden Aulia Shifa

    (Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia)

  • Asmiyenti Djaliasrin Djalil

    (Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia)

Abstract

Breast cancer is a cancer caused by uncontrolled cell growth in breast tissue. In this research, molecular docking has been studied to predict binding affinity of Gnetin C dan trans-resveratrol as active compunds of melinjo seeds to inhibit breast cancer cells Michigan Cancer Fondation-7 (MCF-7). Molecular docking was performed by autodock-vina. The result indicated that Gnetin C and tans-reserveratrol can bind the same amino acid as natural ligan of MCF-7 such as VAL 54B, VAL54B, TYR 55B, TYR 216B, TRP 227B, LEU 306B, LEU 306B, and LEU 306B. Binding affinity of Gnetin C and transresveratrol was -6. and -7.9 respectively, while the natural ligan was -10.0. It means Gnetin C and trans-reserveratrol can bind the protein acid of MCF-7 although the docking energy was lower than the natural ligan. Based on this research, Gnetin C and trans-reserveratrol are potential as anticancer and chemoprevention because they can inhibit some amino acid of cancer cells MCF-7.

Suggested Citation

  • Kintan Nur Romadhona & Nenden Aulia Shifa & Asmiyenti Djaliasrin Djalil, 2018. "Molecular Docking of Gnetin C and Transresveratrol of Melinjo Seeds (Gnetum Gnemon L.) Used as the Inhibitors of Breast Cancer Cells MCF-7," International Journal of Health and Medical Sciences, Mohammad A. H. Khan, vol. 4(3), pages 58-63.
    • Handle: RePEc:apa:ijhmss:2018:p:58-63
    DOI: 10.20469/ijhms.4.30001-3
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